Predementia Brain Changes in Progranulin Mutation: A Systematic Review of Neuroimaging Evidence.
Frontotemporal dementia
Functional neuroimaging
Predementia
Progranulin
Structural neuroimaging
Systematic literature review
Journal
Dementia and geriatric cognitive disorders
ISSN: 1421-9824
Titre abrégé: Dement Geriatr Cogn Disord
Pays: Switzerland
ID NLM: 9705200
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
08
2018
accepted:
30
10
2018
pubmed:
11
1
2019
medline:
18
12
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
Mutations in the progranulin (GRN) gene are a major cause of familial frontotemporal dementia. They result in a loss of progranulin levels and in GRN-related brain degenerative changes that unfold over years if not decades. The aim of our review was to summarize the evidence on emerging functional and structural brain abnormalities in carriers of GRN mutations. We performed a systematic search for studies that used at least one modality (structural MRI, fMRI, fluorodeoxyglucose positron emission tomography, diffusion tensor imaging) to compare mutation carriers to non-carrier controls. Our search produced 13 studies published between 2008 and 2017, the majority cross-sectional, with carrier sample sizes ranging from 5 to 65. Key Messages: The aggregate findings suggest that (1) measurable brain changes are detectable in at least some mutation carriers 20-25 years prior to disease onset; (2) functional/metabolic changes progress more consistently over time than structural changes; (3) the topographic pattern is anterior to posterior, not always asymmetric, and maps onto known functional networks.
Sections du résumé
BACKGROUND
Mutations in the progranulin (GRN) gene are a major cause of familial frontotemporal dementia. They result in a loss of progranulin levels and in GRN-related brain degenerative changes that unfold over years if not decades. The aim of our review was to summarize the evidence on emerging functional and structural brain abnormalities in carriers of GRN mutations.
SUMMARY
We performed a systematic search for studies that used at least one modality (structural MRI, fMRI, fluorodeoxyglucose positron emission tomography, diffusion tensor imaging) to compare mutation carriers to non-carrier controls. Our search produced 13 studies published between 2008 and 2017, the majority cross-sectional, with carrier sample sizes ranging from 5 to 65. Key Messages: The aggregate findings suggest that (1) measurable brain changes are detectable in at least some mutation carriers 20-25 years prior to disease onset; (2) functional/metabolic changes progress more consistently over time than structural changes; (3) the topographic pattern is anterior to posterior, not always asymmetric, and maps onto known functional networks.
Identifiants
pubmed: 30630176
pii: 000494968
doi: 10.1159/000494968
doi:
Substances chimiques
GRN protein, human
0
Progranulins
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-18Informations de copyright
© 2019 S. Karger AG, Basel.