Somnolence-Producing Agents: A 5-Year Study of Prescribing for Medicaid-Insured Children With Attention Deficit Hyperactivity Disorder.
Adolescent
Attention Deficit Disorder with Hyperactivity
/ complications
Child
Child, Preschool
Female
Humans
Hypnotics and Sedatives
/ therapeutic use
Male
Medicaid
Practice Patterns, Physicians'
/ statistics & numerical data
Retrospective Studies
Sleep Initiation and Maintenance Disorders
/ drug therapy
United States
/ epidemiology
United States Food and Drug Administration
ADHD
pediatric
psychopharmacology
sleep
Journal
Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
ISSN: 1532-656X
Titre abrégé: J Pediatr Health Care
Pays: United States
ID NLM: 8709735
Informations de publication
Date de publication:
Historique:
received:
27
07
2018
revised:
08
10
2018
accepted:
12
10
2018
pubmed:
12
1
2019
medline:
2
7
2020
entrez:
12
1
2019
Statut:
ppublish
Résumé
Researchers evaluated the prescribing of medications that induce somnolence to children with attention deficit hyperactivity disorder (ADHD) insured by Medicaid. An observational study of prescription claims for children ages 3-18 with ADHD-associated ICD 9 diagnoses filled between January 1, 2012 and December 31, 2016 in Oregon. There were 14,567 prescriptions written for a 30-day supply of sleep medication for 2,518 children. Most were written for males (66.3%) and to those ages 12-18 (63.8%). Trazodone, hydroxyzine, quetiapine, clonazepam, and amitriptyline were frequently prescribed. There were few prescriptions for zaleplon and zolpidem. Trazodone, hydroxyzine, and amitriptyline are commonly prescribed without clinical efficacy or guidance for children with ADHD. Quetiapine is prescribed off label in sub-therapeutic doses for its somnolence effect. Mental health drugs, which have voluntary formulary guidance in Oregon, and antihistamines on formulary, are more frequently prescribed for children with ADHD than drugs with FDA approval for insomnia.
Identifiants
pubmed: 30630642
pii: S0891-5245(18)30415-2
doi: 10.1016/j.pedhc.2018.10.002
pii:
doi:
Substances chimiques
Hypnotics and Sedatives
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e1-e8Informations de copyright
Copyright © 2018 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.