Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles.

Animals Bone Morphogenetic Proteins / metabolism Cell Movement Cell Survival Ear Ossicles / embryology Endoderm / embryology Gene Deletion Hedgehog Proteins Incus / embryology Malleus / embryology Mice Models, Biological Neural Crest / cytology Organ Specificity Pharynx / embryology Phenotype Signal Transduction Stapes / embryology Time Factors Transforming Growth Factor beta / metabolism
Bone morphogenetic protein 4 Conductive hearing loss Endoderm Middle ear Mouse Neural crest Ossicles Sonic hedgehog

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
22 01 2019
Historique:
received: 22 05 2018
accepted: 24 12 2018
pubmed: 12 1 2019
medline: 10 9 2019
entrez: 12 1 2019
Statut: epublish

Résumé

Defects in the middle ear ossicles - malleus, incus and stapes - can lead to conductive hearing loss. During development, neural crest cells (NCCs) migrate from the dorsal hindbrain to specific locations in pharyngeal arch (PA) 1 and 2, to form the malleus-incus and stapes, respectively. It is unclear how migratory NCCs reach their proper destination in the PA and initiate mesenchymal condensation to form specific ossicles. We show that secreted molecules sonic hedgehog (SHH) and bone morphogenetic protein 4 (BMP4) emanating from the pharyngeal endoderm are important in instructing region-specific NCC condensation to form malleus-incus and stapes, respectively, in mouse. Tissue-specific knockout of

Identifiants

DOI: 10.1242/dev.167965 PMID: 30630826
pubmed: 30630826
pii: dev.167965
doi: 10.1242/dev.167965
pii:
doi:

Substances chimiques

Bone Morphogenetic Proteins 0
Hedgehog Proteins 0
Transforming Growth Factor beta 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Harinarayana Ankamreddy (H)

Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea.
BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

Hyehyun Min (H)

Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea.

Jae Yoon Kim (JY)

Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea.
BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

Xiao Yang (X)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
ORCID: 0000-0002-0298-9831

Eui-Sic Cho (ES)

Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences, Chonbuk National University School of Dentistry, Jeonju, South Korea.

Un-Kyung Kim (UK)

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea.
School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, South Korea.

Jinwoong Bok (J)

Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea bokj@yuhs.ac.
BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
ORCID: 0000-0003-1958-1872

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Region-specific endodermal signals direct...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Region-specific endodermal signals direct...
questionsmedicales.fr › Organes des sens › Oreille › Oreille moyenne › Osselets de l'audition › Region-specific endodermal signals direct...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Endoderme › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Region-specific endodermal signals direct...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines Hedgehog › Region-specific endodermal signals direct...
questionsmedicales.fr › Organes des sens › Oreille › Oreille moyenne › Osselets de l'audition › Incus › Region-specific endodermal signals direct...
questionsmedicales.fr › Organes des sens › Oreille › Oreille moyenne › Osselets de l'audition › Malléus › Region-specific endodermal signals direct...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Region-specific endodermal signals direct...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Region-specific endodermal signals direct...
questionsmedicales.fr › Structures de l'embryon › Crête neurale › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Region-specific endodermal signals direct...
questionsmedicales.fr › Système stomatognathique › Pharynx › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Region-specific endodermal signals direct...
questionsmedicales.fr › Organes des sens › Oreille › Oreille moyenne › Osselets de l'audition › Stapès › Region-specific endodermal signals direct...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Region-specific endodermal signals direct...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Region-specific endodermal signals direct...