Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.
Adolescent
Biomarkers, Tumor
/ genetics
Child
Child, Preschool
Chromosome Aberrations
Cohort Studies
Europe
Female
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Genomics
/ methods
Humans
Infant
Male
Mutation
Oncogene Proteins, Fusion
/ genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/ epidemiology
Prognosis
Transcriptome
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
21
08
2018
accepted:
20
12
2018
pubmed:
12
1
2019
medline:
3
6
2020
entrez:
12
1
2019
Statut:
ppublish
Résumé
Novel biological subtypes and clinically important genetic aberrations (druggable lesions, prognostic factors) have been described in B-other acute lymphoblastic leukemia (ALL) during the last decade; however, due to a lack of studies on unselected cohorts, their population frequency and mutual associations still have to be established. We studied 110 consecutively diagnosed and uniformly treated childhood B-other patients using single nucleotide polymorphism arrays and whole exome/transcriptome sequencing. The frequency of
Identifiants
pubmed: 30630978
pii: haematol.2018.204974
doi: 10.3324/haematol.2018.204974
pmc: PMC6601078
doi:
Substances chimiques
Biomarkers, Tumor
0
Oncogene Proteins, Fusion
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1396-1406Informations de copyright
Copyright© 2019 Ferrata Storti Foundation.
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