Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study.
Adult
Aged
Biomarkers, Tumor
/ genetics
Case-Control Studies
Cohort Studies
Cytidine Deaminase
/ genetics
DNA Ligase ATP
/ genetics
Female
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Humans
Immunoglobulin Class Switching
/ genetics
Lymphocyte Activation
Male
Middle Aged
Multiple Myeloma
/ etiology
Polymorphism, Genetic
Prognosis
Survival Rate
Multiple myeloma
class switch recombination
genetic polymorphisms
overall survival
progression-free survival
susceptibility
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
12
1
2019
medline:
29
7
2020
entrez:
12
1
2019
Statut:
ppublish
Résumé
Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between
Identifiants
pubmed: 30633655
doi: 10.1080/10428194.2018.1551536
doi:
Substances chimiques
Biomarkers, Tumor
0
LIG4 protein, human
0
AICDA (activation-induced cytidine deaminase)
EC 3.5.4.-
Cytidine Deaminase
EC 3.5.4.5
DNA Ligase ATP
EC 6.5.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM