Target animal safety testing of an oral salicylanilide suspension, oxyclozanide, for the treatment of fascioliasis in bovine in China.

Administration, Oral Animals Cattle Dose-Response Relationship, Drug Fascioliasis / drug therapy Female Male Oxyclozanide / administration & dosage Salicylanilides / administration & dosage
Bovine Oxyclozanide suspension Safety Target animal Toxicity risk

Journal

Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 26 02 2018
revised: 26 11 2018
accepted: 02 01 2019
pubmed: 12 1 2019
medline: 21 5 2019
entrez: 12 1 2019
Statut: ppublish

Résumé

The aim of this study was to determine the potential toxicity risk of an oxyclozanide suspension to the target animal, bovine. In this experiment, 32 Simmental beef cattle were fattened and fed a full-price diet without antimicrobial agents. The test cattle were divided into 4 groups, which were treated with 0, 1, 3, and 5 times the recommended dosage through continuous intermittent oral administration at intervals of 2 days. The body weight of the cattle was recorded before and after the experiment, and the weight changes were calculated. The safety of the drugs was evaluated by weight gain, observation of clinical toxicity, haematology, clinical chemistry and histopathology. The results showed that the cattle had different degrees of diarrhoea, loss of appetite and depression after administration. The results of clinicopathology had no significant effect. The results of pathological examination showed that there was a certain degree of damage in the 5 times recommended dose group. The recommended dose was safe to use. Thus, the recommended dose should be given by a single oral administration to ensure the safe use of this drug in the clinic.

Identifiants

DOI: 10.1016/j.yrtph.2019.01.012 PMID: 30634022
pubmed: 30634022
pii: S0273-2300(19)30012-1
doi: 10.1016/j.yrtph.2019.01.012
pii:
doi:

Substances chimiques

Salicylanilides 0
Oxyclozanide 1QS9G4876X
salicylanilide LHP8NEY345

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

21-33

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

Auteurs

Zhen Dong (Z)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.

Jichao Sun (J)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.

Yubin Bai (Y)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.

Weiwei Wang (W)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.

Yueming Zhu (Y)

Zhang Ye Wan He Grass Planting and Animal Husbandry Science & Technology Development Co., Ltd., China.

Bing Li (B)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.

Fusheng Cheng (F)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China.

Xiaojuan Wei (X)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China.

Enliang Song (E)

Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, China.

Haijian Cheng (H)

Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, China.

Fugui Jiang (F)

Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, China.

Xuzheng Zhou (X)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China. Electronic address: zhxuzheng@163.com.

Jiyu Zhang (J)

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China. Electronic address: infzjy@sina.com.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Target animal safety testing of an oral...
questionsmedicales.fr › Eucaryotes › Animaux › Target animal safety testing of an oral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Target animal safety testing of an oral...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Target animal safety testing of an oral...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Parasitoses hépatiques › Fasciolase › Target animal safety testing of an oral...
questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Salicylanilides › Oxyclozanide › Target animal safety testing of an oral...
questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Salicylanilides › Target animal safety testing of an oral...