Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects.
Adaptor Proteins, Vesicular Transport
/ blood
Aged
Biomarkers
/ blood
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ blood
Female
Humans
Lower Extremity
/ blood supply
Male
Middle Aged
Peripheral Arterial Disease
/ blood
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Up-Regulation
Lower limb peripheral artery disease
Sortilin
Type 2 diabetes mellitus
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
11 01 2019
11 01 2019
Historique:
received:
07
11
2018
accepted:
03
01
2019
entrez:
13
1
2019
pubmed:
13
1
2019
medline:
24
4
2019
Statut:
epublish
Résumé
Sortilin is a 95-kDa protein which has recently been linked to circulating cholesterol concentration and lifetime risk of developing significant atherosclerotic disease. Sortilin is found inside different cell types and circulating in blood. Higher circulating sortilin concentration has been found in patients with coronary atherosclerosis compared to control subjects. Sortilin concentration is influenced by statin therapy. We enrolled statin-naïve subjects with type 2 diabetes mellitus and we performed a cross-sectional study to evaluate the association between sortilin levels and the presence of clinically significant lower limb peripheral artery disease (PAD) in a population of statin-free diabetic subjects. Out of the 154 patients enrolled in our study, 80 patients were free from PAD, while 74 had clinically significant PAD. Sortilin concentration was significantly higher in the latter group compared to the former (1.61 ± 0.54 ng/mL versus 0.67 ± 0.30 ng/mL, P < 0.01) and there was a trend toward increased sortilin levels as disease severity increased. The association of sortilin levels with PAD remained after adjusting for major risk factors in a multivariate analysis. We showed that sortilin is significantly and independently associated with the presence of lower limb PAD in a statin-free diabetic population and it may be a promising marker for clinically significant atherosclerosis of the lower limbs. Further studies are needed to confirm this finding and to evaluate its clinical usefulness.
Sections du résumé
BACKGROUND
Sortilin is a 95-kDa protein which has recently been linked to circulating cholesterol concentration and lifetime risk of developing significant atherosclerotic disease. Sortilin is found inside different cell types and circulating in blood. Higher circulating sortilin concentration has been found in patients with coronary atherosclerosis compared to control subjects. Sortilin concentration is influenced by statin therapy.
METHODS
We enrolled statin-naïve subjects with type 2 diabetes mellitus and we performed a cross-sectional study to evaluate the association between sortilin levels and the presence of clinically significant lower limb peripheral artery disease (PAD) in a population of statin-free diabetic subjects.
RESULTS
Out of the 154 patients enrolled in our study, 80 patients were free from PAD, while 74 had clinically significant PAD. Sortilin concentration was significantly higher in the latter group compared to the former (1.61 ± 0.54 ng/mL versus 0.67 ± 0.30 ng/mL, P < 0.01) and there was a trend toward increased sortilin levels as disease severity increased. The association of sortilin levels with PAD remained after adjusting for major risk factors in a multivariate analysis.
CONCLUSIONS
We showed that sortilin is significantly and independently associated with the presence of lower limb PAD in a statin-free diabetic population and it may be a promising marker for clinically significant atherosclerosis of the lower limbs. Further studies are needed to confirm this finding and to evaluate its clinical usefulness.
Identifiants
pubmed: 30634965
doi: 10.1186/s12933-019-0805-5
pii: 10.1186/s12933-019-0805-5
pmc: PMC6329108
doi:
Substances chimiques
Adaptor Proteins, Vesicular Transport
0
Biomarkers
0
sortilin
Z020Y8WIJ4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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