CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)
Amyotrophic Lateral Sclerosis
/ genetics
Animals
Astrocytes
/ pathology
Brain
/ pathology
Extracellular Vesicles
/ enzymology
Glycoproteins
/ metabolism
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myelin Sheath
/ metabolism
Neurons
/ pathology
Protein Folding
Proteomics
Spinal Cord
/ pathology
Superoxide Dismutase-1
/ chemistry
amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease)
astrocyte
central nervous system (CNS)
exosome (vesicle)
extracellular vesicles
neurodegeneration
protein homeostasis
proteomics
secretion
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 03 2019
08 03 2019
Historique:
received:
10
07
2018
revised:
02
01
2019
pmc-release:
08
03
2020
pubmed:
13
1
2019
medline:
21
5
2019
entrez:
13
1
2019
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are secreted by myriad cells in culture and also by unicellular organisms, and their identification in mammalian fluids suggests that EV release also occurs at the organism level. However, although it is clearly important to better understand EVs' roles in organismal biology, EVs in solid tissues have received little attention. Here, we modified a protocol for EV isolation from primary neural cell culture to collect EVs from frozen whole murine and human neural tissues by serial centrifugation and purification on a sucrose gradient. Quantitative proteomics comparing brain-derived EVs from nontransgenic (NTg) and a transgenic amyotrophic lateral sclerosis (ALS) mouse model, superoxide dismutase 1 (SOD1)
Identifiants
pubmed: 30635404
pii: S0021-9258(20)38997-3
doi: 10.1074/jbc.RA118.004825
pmc: PMC6416428
doi:
Substances chimiques
Glycoproteins
0
Superoxide Dismutase-1
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3744-3759Informations de copyright
© 2019 Silverman et al.
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