Understanding the evidence for medical cannabis and cannabis-based medicines for the treatment of chronic non-cancer pain.
Cannabis
Cannabis-based medicines
Chronic pain
Medical cannabis
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
28
08
2018
accepted:
21
11
2018
pubmed:
13
1
2019
medline:
6
6
2019
entrez:
13
1
2019
Statut:
ppublish
Résumé
The use of medical cannabis and cannabis-based medicines has received increasing interest in recent years; with a corresponding surge in the number of studies and reviews conducted in the field. Despite this growth in evidence, the findings and conclusions of these studies have been inconsistent. In this paper, we outline the current evidence for medical cannabis and cannabis-based medicines in the treatment and management of chronic non-cancer pain. We discuss limitations of the current evidence, including limitations of randomised control trials in the field, limits on generalisability of previous findings and common issues such as problems with measurements of dose and type of cannabinoids. We discuss future directions for medicinal cannabinoid research, including addressing limitations in trial design; developing frameworks to monitor for use disorder and other unintended outcomes; and considering endpoints other than 30% or 50% reductions in pain severity.
Identifiants
pubmed: 30635715
doi: 10.1007/s00406-018-0960-9
pii: 10.1007/s00406-018-0960-9
doi:
Substances chimiques
Cannabinoid Receptor Modulators
0
Cannabinoids
0
Medical Marijuana
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-144Subventions
Organisme : National Health and Medical Research Council
ID : 1119992
Organisme : National Health and Medical Research Council
ID : 1104600
Organisme : National Health and Medical Research Council
ID : 113243
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