AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper.
Animals
Asthma
/ immunology
Bacteria
/ genetics
Child
Child, Preschool
Diet
Epithelium
/ immunology
Female
Gastrointestinal Microbiome
/ immunology
Host Microbial Interactions
/ immunology
Humans
Hygiene Hypothesis
Immunity, Cellular
Infant
Male
Micronutrients
Mucous Membrane
/ immunology
Neoplasms
/ immunology
Phylogeny
allergy
cancer
hygiene hypothesis
microbiota
oncoimmunology
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
14
12
2018
revised:
27
12
2018
accepted:
28
12
2018
pubmed:
13
1
2019
medline:
9
6
2020
entrez:
13
1
2019
Statut:
ppublish
Résumé
The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
Identifiants
pubmed: 30636005
doi: 10.1111/all.13718
pmc: PMC6563061
doi:
Substances chimiques
Micronutrients
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1037-1051Subventions
Organisme : Austrian Science Fund
ID : KLI284
Pays : International
Organisme : NIHR National Institute for Health Research
ID : IS-BRC-1215-20006
Pays : International
Organisme : Cancer Research UK
ID : C30122/A15774
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000758
Pays : United Kingdom
Organisme : Aimwell Charitable Trust and Emailie Gutterman Memorial Endowed Fund
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA196266
Pays : United States
Organisme : Austrian Science Fund
ID : F4606-B28
Pays : International
Organisme : Medical Research Council
ID : G0501494
Pays : United Kingdom
Organisme : Austrian Science Fund
ID : P23398-B11
Pays : International
Organisme : Stop Cancer-USC Norris Comprehensive Cancer Center
Pays : International
Organisme : European Academy of Allergy ande Clinical immunology
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : HA 2393/6-1
Pays : International
Organisme : Israel Cancer Association
ID : #20161131
Pays : International
Organisme : EUE, FRW and EJJ are experts of the Austrian Microbiome initiative amici.
Pays : International
Organisme : Medical Research Council
ID : G0200486
Pays : United Kingdom
Organisme : IGEM Therapeutics Ltd
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA181115
Pays : United States
Organisme : Cancer Research UK
ID : C30122/A11527
Pays : United Kingdom
Organisme : Israel Science Foundation
ID : #213/05
Pays : International
Organisme : Breast Cancer Now
ID : C10355/A15587
Pays : United Kingdom
Organisme : American Society of Hematology
Pays : International
Organisme : Israel Science Foundation "Center of Excellence /MOKED"
Pays : International
Organisme : The Academy of Medical Sciences
Pays : International
Organisme : Medical Research Council
ID : MR/L023091/1
Pays : United Kingdom
Organisme : Israel Ministry of Science, Technology and Space "Personalized Medicine"
Pays : International
Organisme : Departament de Salut, Generalitat de Catalunya
ID : SLT002/16/00232
Pays : International
Organisme : Medical Research Council
ID : G1100090
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Allergy Published by John Wiley & Sons Ltd.
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