Free triiodothyronine is associated with the occurrence and remission of nonalcoholic fatty liver disease in euthyroid women.
Alanine Transaminase
/ metabolism
Cross-Sectional Studies
Disease Progression
Female
Humans
Liver Cirrhosis, Alcoholic
/ etiology
Middle Aged
Non-alcoholic Fatty Liver Disease
/ blood
Remission, Spontaneous
Risk Factors
Thyroid Gland
/ physiology
Thyrotropin
/ metabolism
Thyroxine
/ metabolism
Triiodothyronine
/ metabolism
Ultrasonography
cohort study
euthyroidism
free triiodothyronine
nonalcoholic fatty liver disease
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
31
07
2018
revised:
01
11
2018
accepted:
23
11
2018
pubmed:
14
1
2019
medline:
18
12
2019
entrez:
14
1
2019
Statut:
ppublish
Résumé
The association between nonalcoholic fatty liver disease (NAFLD) and free triiodothyronine (FT3) in euthyroid subjects was in dispute. We aimed to investigate this issue in a population-based cohort study. A total of 3144 euthyroid subjects at baseline from the Shanghai Nicheng Atherosclerosis Study were selected for the cross-sectional analysis, and 2089 subjects being followed up after 2.2 years were selected for the longitudinal analysis. NAFLD was diagnosed by ultrasound. The cut-off point of elevated alanine aminotransferase (ALT) level was 40 U/L. The FIB-4 index was used to assess the risk of advanced liver fibrosis. Age-adjusted mean levels of FT3 and FT3/free thyroxine (FT4) ratio were higher in subjects with NAFLD than those without NAFLD and linearly increased with a higher risk of NAFLD progression (assessed by levels of ALT and FIB-4 index) in euthyroid women but not in men. After adjustment for confounding variables, FT3 levels significantly increased with the presence of NAFLD (β = 0.1, P < 0.001) and linearly increased with a higher risk of NAFLD progression in euthyroid women. After a 2.2-year follow-up, FT3 levels increased with the occurrence of NAFLD (mean change percentage: 1.4%) and decreased with the remission of NAFLD (mean change percentage: -2.7%) in euthyroid women. There are positive associations of FT3 levels with NAFLD and the risk of NAFLD progression in euthyroid women. The changes in FT3 levels with the alteration of NAFLD status may be an adaptive response to maintain energy and metabolic homeostasis.
Sections du résumé
BACKGROUND
BACKGROUND
The association between nonalcoholic fatty liver disease (NAFLD) and free triiodothyronine (FT3) in euthyroid subjects was in dispute. We aimed to investigate this issue in a population-based cohort study.
MATERIALS AND METHODS
METHODS
A total of 3144 euthyroid subjects at baseline from the Shanghai Nicheng Atherosclerosis Study were selected for the cross-sectional analysis, and 2089 subjects being followed up after 2.2 years were selected for the longitudinal analysis. NAFLD was diagnosed by ultrasound. The cut-off point of elevated alanine aminotransferase (ALT) level was 40 U/L. The FIB-4 index was used to assess the risk of advanced liver fibrosis.
RESULTS
RESULTS
Age-adjusted mean levels of FT3 and FT3/free thyroxine (FT4) ratio were higher in subjects with NAFLD than those without NAFLD and linearly increased with a higher risk of NAFLD progression (assessed by levels of ALT and FIB-4 index) in euthyroid women but not in men. After adjustment for confounding variables, FT3 levels significantly increased with the presence of NAFLD (β = 0.1, P < 0.001) and linearly increased with a higher risk of NAFLD progression in euthyroid women. After a 2.2-year follow-up, FT3 levels increased with the occurrence of NAFLD (mean change percentage: 1.4%) and decreased with the remission of NAFLD (mean change percentage: -2.7%) in euthyroid women.
CONCLUSIONS
CONCLUSIONS
There are positive associations of FT3 levels with NAFLD and the risk of NAFLD progression in euthyroid women. The changes in FT3 levels with the alteration of NAFLD status may be an adaptive response to maintain energy and metabolic homeostasis.
Substances chimiques
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
Alanine Transaminase
EC 2.6.1.2
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13070Subventions
Organisme : National Natural Science Foundation of China
ID : 81202273
Organisme : Shanghai Pujiang Talent Program
ID : 12PJ1407000
Organisme : Shanghai Health and Family Planning Commission
ID : 2013ZYJB1001
Organisme : Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University
ID : YG2015MS18
Informations de copyright
© 2019 Stichting European Society for Clinical Investigation Journal Foundation.