Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial.
Administration, Cutaneous
Adult
Back
Dermatitis, Irritant
/ diagnosis
Emollients
/ pharmacology
Female
Forearm
Healthy Volunteers
Humans
Irritants
/ toxicity
Male
Severity of Illness Index
Skin
/ drug effects
Skin Cream
/ pharmacology
Sodium Dodecyl Sulfate
/ toxicity
Treatment Outcome
Water Loss, Insensible
/ drug effects
Young Adult
Journal
The British journal of dermatology
ISSN: 1365-2133
Titre abrégé: Br J Dermatol
Pays: England
ID NLM: 0004041
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
accepted:
09
01
2019
pubmed:
15
1
2019
medline:
29
8
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Sodium lauryl sulfate (SLS)-induced contact dermatitis is a commonly used model for testing the effects of different topical formulations. According to the guidelines, the volar forearms are the preferred testing site; however, other anatomical locations have been used in previous research, particularly the upper back as the clinically used site for testing different antigens. To investigate the existence of anatomical variations of the skin response to irritation and its effects on the response to treatment. Irritation was induced with SLS on symmetrical sites on both forearms and sides of the upper back with additional sites exposed to water as controls. Half of the sites were treated with emollient cream while the other half were left untreated. Irritation was assessed using bioengineering methods and clinical scoring. The trial was registered at ClinicalTrials.gov as NCT03231813. Upper back skin showed higher reactivity to irritants with stronger barrier disruption (measured by Tewameter The skin's reaction to irritant and recovery was dependent on anatomical location. The location where testing was conducted should always be reported, as treatments tested across different locations could not be directly compared with each other.
Sections du résumé
BACKGROUND
Sodium lauryl sulfate (SLS)-induced contact dermatitis is a commonly used model for testing the effects of different topical formulations. According to the guidelines, the volar forearms are the preferred testing site; however, other anatomical locations have been used in previous research, particularly the upper back as the clinically used site for testing different antigens.
OBJECTIVES
To investigate the existence of anatomical variations of the skin response to irritation and its effects on the response to treatment.
METHODS
Irritation was induced with SLS on symmetrical sites on both forearms and sides of the upper back with additional sites exposed to water as controls. Half of the sites were treated with emollient cream while the other half were left untreated. Irritation was assessed using bioengineering methods and clinical scoring. The trial was registered at ClinicalTrials.gov as NCT03231813.
RESULTS
Upper back skin showed higher reactivity to irritants with stronger barrier disruption (measured by Tewameter
CONCLUSIONS
The skin's reaction to irritant and recovery was dependent on anatomical location. The location where testing was conducted should always be reported, as treatments tested across different locations could not be directly compared with each other.
Substances chimiques
Emollients
0
Irritants
0
Sodium Dodecyl Sulfate
368GB5141J
Banques de données
ClinicalTrials.gov
['NCT03231813']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-185Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 British Association of Dermatologists.