DPP10 is a new regulator of Nav1.5 channels in human heart.
Action potential
DPP10
Human heart
Nav1.5 channel
Rat ventricular myocytes
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
20
06
2018
revised:
14
12
2018
accepted:
27
12
2018
pubmed:
15
1
2019
medline:
7
1
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Cardiac accessory β-subunits are part of macromolecular Nav1.5 channel complexes modulating biophysical properties and contributing to arrhythmias. Recent studies demonstrated the structural interaction between β-subunits of Na We assessed DPP10 expression in the healthy and diseased human heart and we studied the functional effects of DPP10 on the Na DPP10 mRNA and proteins were detected in human ventricle, with higher levels in patients with heart failure. In rat cardiomyocytes, DPP10ad significantly reduced upstroke velocity of action potentials indicating reduction in Na We provide first evidence that DPP10 interacts with Nav1.5 channels, linking Na
Sections du résumé
BACKGROUND
Cardiac accessory β-subunits are part of macromolecular Nav1.5 channel complexes modulating biophysical properties and contributing to arrhythmias. Recent studies demonstrated the structural interaction between β-subunits of Na
METHODS
We assessed DPP10 expression in the healthy and diseased human heart and we studied the functional effects of DPP10 on the Na
RESULTS
DPP10 mRNA and proteins were detected in human ventricle, with higher levels in patients with heart failure. In rat cardiomyocytes, DPP10ad significantly reduced upstroke velocity of action potentials indicating reduction in Na
CONCLUSION
We provide first evidence that DPP10 interacts with Nav1.5 channels, linking Na
Identifiants
pubmed: 30638748
pii: S0167-5273(18)34013-0
doi: 10.1016/j.ijcard.2018.12.072
pii:
doi:
Substances chimiques
NAV1.5 Voltage-Gated Sodium Channel
0
RNA
63231-63-0
DPP10 protein, human
EC 3.4.14.-
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
EC 3.4.14.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
68-73Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.