Pulsed electric fields for cardiac ablation and beyond: A state-of-the-art review.
Ablation
Electroporation
Irreversible electroporation
Pulsed electric fields
Radiofrequency
Journal
Heart rhythm
ISSN: 1556-3871
Titre abrégé: Heart Rhythm
Pays: United States
ID NLM: 101200317
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
11
11
2018
pubmed:
15
1
2019
medline:
4
11
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Irreversible electroporation (IRE) occurs when a strong, pulsed electric field (PEF) causes permeabilization of the cell membrane, leading to cellular homeostasis disruption and cell death. IRE is a Food and Drug Administration-approved treatment of tumor ablation and has been gaining attention in cardiology as an ablation modality. Applications of PEF in cardiology are vast and include atrial fibrillation, ventricular fibrillation, septal ablation, and targeting vascular structures. PEF has appealing characteristics, including the ability to be tissue specific and its nonthermal nature. This review provides information on the biophysics and mechanisms of IRE, summarizes key studies and applications to date, and provides insight into future applications.
Identifiants
pubmed: 30641148
pii: S1547-5271(19)30012-8
doi: 10.1016/j.hrthm.2019.01.012
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1112-1120Informations de copyright
Copyright © 2019 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.