Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer.
EMT
bladder cancer
epigenetics
lncRNA
miRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jan 2019
13 Jan 2019
Historique:
received:
12
12
2018
revised:
02
01
2019
accepted:
09
01
2019
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Bladder cancer is one of the most incident neoplasms worldwide, and its treatment remains a significant challenge, since the mechanisms underlying disease progression are still poorly understood. The epithelial to mesenchymal transition (EMT) has been proven to play an important role in the tumorigenic process, particularly in cancer cell invasiveness and metastatic potential. Several studies have reported the importance of epigenetic mechanisms and enzymes, which orchestrate them in several features of cancer cells and, specifically, in EMT. In this paper, we discuss the epigenetic enzymes, protein-coding and non-coding genes, and mechanisms altered in the EMT process occurring in bladder cancer cells, as well as its implications, which allows for improved understanding of bladder cancer biology and for the development of novel targeted therapies.
Identifiants
pubmed: 30642115
pii: ijms20020297
doi: 10.3390/ijms20020297
pmc: PMC6358899
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Research Center of Portuguese Oncology Institute of Porto
ID : CI-IPOP-FBGEBC-27
Organisme : Research Center of Portuguese Oncology Institute of Porto
ID : PI 74-CI-IPOP-19-2016
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/112673/2015
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/132751/2017
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