Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimer Disease / pathology Amyloid beta-Peptides / metabolism Biomarkers Blood-Brain Barrier / metabolism Brain / pathology Cerebrovascular Circulation / physiology Humans National Institute on Aging (U.S.) United States Vascular Diseases / physiopathology White Matter / pathology
Alzheimer's disease Biomarkers Blood-brain barrier Cerebral blood flow MRI Vascular

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
01 2019
Historique:
received: 13 06 2018
accepted: 31 07 2018
entrez: 16 1 2019
pubmed: 16 1 2019
medline: 19 7 2019
Statut: ppublish

Résumé

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize. We suggest that these vascular biomarkers should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.

Identifiants

DOI: 10.1016/j.jalz.2018.07.222 PMID: 30642436 PMC: PMC6338083
pubmed: 30642436
pii: S1552-5260(18)33495-2
doi: 10.1016/j.jalz.2018.07.222
pmc: PMC6338083
mid: NIHMS1505478
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158-167

Subventions

Organisme : Medical Research Council
ID : G1002605
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS100447
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_14095
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS034467
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS090904
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100459
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG050745
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS110049
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059621
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG052350
Pays : United States
Organisme : Medical Research Council
ID : G0502157
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS100605
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG023084
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002002
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG039452
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG039452
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048769
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005146
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS037853
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034179
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053938
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095441
Pays : United States
Organisme : Chief Scientist Office
ID : ETM/326
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG040282
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054548
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : Medical Research Council
ID : MR/J006971/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100540
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG058969
Pays : United States
Organisme : Medical Research Council
ID : G0900652
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG054069
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : Medical Research Council
ID : G108/613
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR002003
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052409
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS034179
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG057468
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS089323
Pays : United States
Organisme : Medical Research Council
ID : G0400074
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG052573
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100366
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG056952
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057575
Pays : United States
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K015397/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0500247
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

Informations de copyright

Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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Auteurs

Melanie D Sweeney (MD)

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Axel Montagne (A)

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Abhay P Sagare (AP)

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Daniel A Nation (DA)

Department of Psychology, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.

Lon S Schneider (LS)

Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Helena C Chui (HC)

Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Michael G Harrington (MG)

Huntington Medical Research Institutes, Pasadena, CA, USA.

Judy Pa (J)

Laboratory of Neuro Imaging (LONI), Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Meng Law (M)

Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Danny J J Wang (DJJ)

Laboratory of Neuro Imaging (LONI), Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Russell E Jacobs (RE)

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Fergus N Doubal (FN)

Neuroimaging Sciences and Brain Research Imaging Center, Division of Neuroimaging Sciences, Center for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, UK.

Joel Ramirez (J)

LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Sandra E Black (SE)

Department of Medicine (Neurology), Hurvitz Brain Sciences Program, Canadian Partnership for Stroke Recovery, and LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto Dementia Research Alliance, University of Toronto, Toronto, Canada.

Maiken Nedergaard (M)

Section for Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY, USA.

Helene Benveniste (H)

Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.

Martin Dichgans (M)

Institute for Stroke and Dementia Research (ISD), Ludwing-Maximilians-University Munich, Munich, Germany.

Costantino Iadecola (C)

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

Seth Love (S)

Institute of Clinical Neurosciences, University of Bristol, School of Medicine, Level 2 Learning and Research, Southmead Hospital, Bristol, UK.

Philip M Bath (PM)

Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK; Stroke, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK.

Hugh S Markus (HS)

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

Rustam Al-Shahi Salman (R)

Neuroimaging Sciences and Brain Research Imaging Center, Division of Neuroimaging Sciences, Center for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, UK.

Stuart M Allan (SM)

Faculty of Biology, Medicine and Health, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, UK.

Terence J Quinn (TJ)

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Rajesh N Kalaria (RN)

Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

David J Werring (DJ)

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, UK.

Roxana O Carare (RO)

Faculty of Medicine, University of Southampton, Southampton, UK.

Rhian M Touyz (RM)

British Heart Foundation, Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.

Steve C R Williams (SCR)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Michael A Moskowitz (MA)

Stroke and Neurovascular Regulation Laboratory, Departments of Radiology and Neurology Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Zvonimir S Katusic (ZS)

Department of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA.

Sarah E Lutz (SE)

Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.

Orly Lazarov (O)

Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.

Richard D Minshall (RD)

Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA; Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.

Jalees Rehman (J)

Department of Pharmacology, The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL, USA; Department of Medicine, The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL, USA.

Thomas P Davis (TP)

Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

Cheryl L Wellington (CL)

Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.

Hector M González (HM)

Department of Neurosciences, University of California, San Diego, CA, USA.

Chun Yuan (C)

Department of Radiology, University of Washington, Seattle, WA, USA.

Samuel N Lockhart (SN)

Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Alzheimer's Disease Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Timothy M Hughes (TM)

Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Alzheimer's Disease Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Christopher L H Chen (CLH)

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Memory Aging and Cognition Centre, National University Health System, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Memory Aging and Cognition Centre, National University Health System, Singapore.

Perminder Sachdev (P)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Australia, Sydney, Australia.

John T O'Brien (JT)

Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Ingmar Skoog (I)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

Leonardo Pantoni (L)

"L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Deborah R Gustafson (DR)

Department of Neurology, State University of New York-Downstate Medical Center, Brooklyn, NY, USA.

Geert Jan Biessels (GJ)

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Anders Wallin (A)

Institute of Neuroscience and Physiology, University of Gothenburg, Gothenberg, Sweden.

Eric E Smith (EE)

Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.

Vincent Mok (V)

Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China; Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Adrian Wong (A)

Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China.

Peter Passmore (P)

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Frederick Barkof (F)

Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Institutes of Neurology and Healthcare Engineering, University College London, London, UK.

Majon Muller (M)

Section of Geriatrics, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.

Monique M B Breteler (MMB)

Department of Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.

Gustavo C Román (GC)

Department of Neurology, Methodist Neurological Institute, Houston, TX, USA.

Edith Hamel (E)

Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, QC, Canada.

Sudha Seshadri (S)

The Framingham Heart Study, Framingham, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

Rebecca F Gottesman (RF)

Departments of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD, USA.

Mark A van Buchem (MA)

Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

Zoe Arvanitakis (Z)

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Julie A Schneider (JA)

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Lester R Drewes (LR)

Laboratory of Cerebral Vascular Biology, Department of Biomedical Sciences, University of Minnesota Medical School Duluth, Duluth, MN, USA.

Vladimir Hachinski (V)

Division of Neurology, Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada.

Caleb E Finch (CE)

Leonard Davis School of Gerontology, Dornsife College, University of Southern California, Los Angeles, CA, USA.

Arthur W Toga (AW)

Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging (LONI), Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Joanna M Wardlaw (JM)

Neuroimaging Sciences and Brain Research Imaging Center, Division of Neuroimaging Sciences, Center for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, UK.

Berislav V Zlokovic (BV)

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address: zlokovic@usc.edu.

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Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
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Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Gouvernement › Agences gouvernementale américaines › Department of Health and Human Services (USA) › Public Health Service (USA) › National Institutes of Health (USA) › National Institute on Aging (USA) › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Vascular dysfunction-The disregarded partner...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Vascular dysfunction-The disregarded partner...