Edith Hamel

Affiliations

Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, QC H3A 2B4, Canada. Electronic address: edith.hamel@mcgill.ca.

Publications (13)

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

European journal of medicinal chemistry

Avec: Michela Puxeddu , Hongliang Shen , Ruoli Bai , Antonio Coluccia , Marianna Nalli , Carmela Mazzoccoli , Eleonora Da Pozzo , Chiara Cavallini , Claudia Martini , Viviana Orlando , Stefano Biagioni , Cristina Mazzoni , Addolorata Maria Luce Coluccia , Ernest Hamel , Te Liu , Romano Silvestri , Giuseppe La Regina

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

ACS omega

Avec: Wolfgang Dohle , Andrea E Prota , Grégory Menchon , Ernest Hamel , Michel O Steinmetz , Barry V L Potter

How reliable is cerebral blood flow to map changes in neuronal activity?

Autonomic neuroscience : basic & clinical

Avec: Clotilde Lecrux , Miled Bourourou , Edith Hamel

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Melanie D Sweeney , Axel Montagne , Abhay P Sagare , Daniel A Nation , Lon S Schneider , Helena C Chui , Michael G Harrington , Judy Pa , Meng Law , Danny J J Wang , Russell E Jacobs , Fergus N Doubal , Joel Ramirez , Sandra E Black , Maiken Nedergaard , Helene Benveniste , Martin Dichgans , Costantino Iadecola , Seth Love , Philip M Bath , Hugh S Markus , Rustam Al-Shahi Salman , Stuart M Allan , Terence J Quinn , Rajesh N Kalaria , David J Werring , Roxana O Carare , Rhian M Touyz , Steve C R Williams , Michael A Moskowitz , Zvonimir S Katusic , Sarah E Lutz , Orly Lazarov , Richard D Minshall , Jalees Rehman , Thomas P Davis , Cheryl L Wellington , Hector M González , Chun Yuan , Samuel N Lockhart , Timothy M Hughes , Christopher L H Chen , Perminder Sachdev , John T O'Brien , Ingmar Skoog , Leonardo Pantoni , Deborah R Gustafson , Geert Jan Biessels , Anders Wallin , Eric E Smith , Vincent Mok , Adrian Wong , Peter Passmore , Frederick Barkof , Majon Muller , Monique M B Breteler , Gustavo C Román , Edith Hamel , Sudha Seshadri , Rebecca F Gottesman , Mark A van Buchem , Zoe Arvanitakis , Julie A Schneider , Lester R Drewes , Vladimir Hachinski , Caleb E Finch , Arthur W Toga , Joanna M Wardlaw , Berislav V Zlokovic

Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease.

Neurobiology of disease

Avec: Jessika Royea , Pauline Martinot , Edith Hamel

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.

Journal of natural products

Avec: Blake A Winn , Laxman Devkota , Bunnarack Kuch , Matthew T MacDonough , Tracy E Strecker , Yifan Wang , Zhe Shi , Jeni L Gerberich , Deboprosad Mondal , Alejandro J Ramirez , Ernest Hamel , David J Chaplin , Peter Davis , Ralph P Mason , Mary Lynn Trawick , Kevin G Pinney

New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action.

Bioorganic chemistry

Avec: Giuseppe Daidone , Antonella D'Anneo , Maria Valeria Raimondi , Demetrio Raffa , Ernest Hamel , Fabiana Plescia , Marianna Lauricella , Benedetta Maggio

A functional cerebral endothelium is necessary to protect against cognitive decline.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Avec: Lianne J Trigiani , Miled Bourourou , María Lacalle-Aurioles , Clotilde Lecrux , Amy Hynes , Shoshana Spring , Darren J Fernandes , John G Sled , Frédéric Lesage , Markus Schwaninger , Edith Hamel

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development.

Pharmacology & therapeutics

Avec: Mudasir Nabi Peerzada , Ernest Hamel , Ruoli Bai , Claudiu T Supuran , Amir Azam

A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents.

European journal of medicinal chemistry

Avec: Romeo Romagnoli , Paola Oliva , Maria Kimatrai Salvador , Stefano Manfredini , Chiara Padroni , Andrea Brancale , Salvatore Ferla , Ernest Hamel , Roberto Ronca , Federica Maccarinelli , Fatlum Rruga , Elena Mariotto , Giampietro Viola , Roberta Bortolozzi

Addressing sexuality and sexual health with migrants. Practice guidelines.

Infectious diseases now

Avec: Hugues Cordel , Claire Tantet , Tatiana Stempak , Eric Billaud , Emilie Mosnier , Florence Huber , Sophie Florence , Delphine Leclerc , Anaeza Freire-Maresca , Hélène de Champs Léger , Marie Ahouanto , François Linard , Marie Petruzzi , Emmanuelle Hamel , Emmanuelle Le Lay , Nathalie Lydié , Anna Simon , Leslie Alcouffe , Nicolas Vignier

Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.

Cell death & disease

Avec: Xin-Kang Tong , Jessika Royea , Edith Hamel

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-

Molecules (Basel, Switzerland)

Avec: Farhana Islam , Arpit Doshi , Andrew J Robles , Tasdique M Quadery , Xin Zhang , Xilin Zhou , Ernest Hamel , Susan L Mooberry , Aleem Gangjee

Réseau de co-auteurs

Ernest Hamel 7 collaborations

Ruoli Bai 2 collaborations

Clotilde Lecrux 2 collaborations

Miled Bourourou 2 collaborations

Jessika Royea 2 collaborations

Michela Puxeddu 1 collaboration

Hongliang Shen 1 collaboration

Antonio Coluccia 1 collaboration

Marianna Nalli 1 collaboration

Carmela Mazzoccoli 1 collaboration

Eleonora Da Pozzo 1 collaboration

Chiara Cavallini 1 collaboration

Claudia Martini 1 collaboration

Viviana Orlando 1 collaboration

Stefano Biagioni 1 collaboration

Cristina Mazzoni 1 collaboration

Addolorata Maria Luce Coluccia 1 collaboration

Te Liu 1 collaboration

Romano Silvestri 1 collaboration

Giuseppe La Regina 1 collaboration

Wolfgang Dohle 1 collaboration

Andrea E Prota 1 collaboration

Grégory Menchon 1 collaboration

Michel O Steinmetz 1 collaboration

Barry V L Potter 1 collaboration

Melanie D Sweeney 1 collaboration

Axel Montagne 1 collaboration

Abhay P Sagare 1 collaboration

Daniel A Nation 1 collaboration

Lon S Schneider 1 collaboration

Helena C Chui 1 collaboration

Michael G Harrington 1 collaboration

Judy Pa 1 collaboration

Meng Law 1 collaboration

Danny J J Wang 1 collaboration

Russell E Jacobs 1 collaboration

Fergus N Doubal 1 collaboration

Joel Ramirez 1 collaboration

Sandra E Black 1 collaboration

Maiken Nedergaard 1 collaboration

Helene Benveniste 1 collaboration

Martin Dichgans 1 collaboration

Costantino Iadecola 1 collaboration

Seth Love 1 collaboration

Philip M Bath 1 collaboration

Hugh S Markus 1 collaboration

Rustam Al-Shahi Salman 1 collaboration

Stuart M Allan 1 collaboration

Terence J Quinn 1 collaboration

Rajesh N Kalaria 1 collaboration

David J Werring 1 collaboration

Roxana O Carare 1 collaboration

Rhian M Touyz 1 collaboration

Steve C R Williams 1 collaboration

Michael A Moskowitz 1 collaboration

Zvonimir S Katusic 1 collaboration

Sarah E Lutz 1 collaboration

Orly Lazarov 1 collaboration

Richard D Minshall 1 collaboration

Jalees Rehman 1 collaboration

Thomas P Davis 1 collaboration

Cheryl L Wellington 1 collaboration

Hector M González 1 collaboration

Chun Yuan 1 collaboration

Samuel N Lockhart 1 collaboration

Timothy M Hughes 1 collaboration

Christopher L H Chen 1 collaboration

Perminder Sachdev 1 collaboration

John T O'Brien 1 collaboration

Ingmar Skoog 1 collaboration

Leonardo Pantoni 1 collaboration

Deborah R Gustafson 1 collaboration

Geert Jan Biessels 1 collaboration

Anders Wallin 1 collaboration

Eric E Smith 1 collaboration

Vincent Mok 1 collaboration

Adrian Wong 1 collaboration

Peter Passmore 1 collaboration

Frederick Barkof 1 collaboration

Majon Muller 1 collaboration

Monique M B Breteler 1 collaboration

Gustavo C Román 1 collaboration

Sudha Seshadri 1 collaboration

Rebecca F Gottesman 1 collaboration

Mark A van Buchem 1 collaboration

Zoe Arvanitakis 1 collaboration

Julie A Schneider 1 collaboration

Lester R Drewes 1 collaboration

Vladimir Hachinski 1 collaboration

Caleb E Finch 1 collaboration

Arthur W Toga 1 collaboration

Joanna M Wardlaw 1 collaboration

Berislav V Zlokovic 1 collaboration

Pauline Martinot 1 collaboration

Blake A Winn 1 collaboration

Laxman Devkota 1 collaboration

Bunnarack Kuch 1 collaboration

Matthew T MacDonough 1 collaboration

Tracy E Strecker 1 collaboration

Yifan Wang 1 collaboration

Zhe Shi 1 collaboration

Jeni L Gerberich 1 collaboration

Deboprosad Mondal 1 collaboration

Alejandro J Ramirez 1 collaboration

David J Chaplin 1 collaboration

Peter Davis 1 collaboration

Ralph P Mason 1 collaboration

Mary Lynn Trawick 1 collaboration

Kevin G Pinney 1 collaboration

Giuseppe Daidone 1 collaboration

Antonella D'Anneo 1 collaboration

Maria Valeria Raimondi 1 collaboration

Demetrio Raffa 1 collaboration

Fabiana Plescia 1 collaboration

Marianna Lauricella 1 collaboration

Benedetta Maggio 1 collaboration

Lianne J Trigiani 1 collaboration

María Lacalle-Aurioles 1 collaboration

Amy Hynes 1 collaboration

Shoshana Spring 1 collaboration

Darren J Fernandes 1 collaboration

John G Sled 1 collaboration

Frédéric Lesage 1 collaboration

Markus Schwaninger 1 collaboration

Mudasir Nabi Peerzada 1 collaboration

Claudiu T Supuran 1 collaboration

Amir Azam 1 collaboration

Romeo Romagnoli 1 collaboration

Paola Oliva 1 collaboration

Maria Kimatrai Salvador 1 collaboration

Stefano Manfredini 1 collaboration

Chiara Padroni 1 collaboration

Andrea Brancale 1 collaboration

Salvatore Ferla 1 collaboration

Roberto Ronca 1 collaboration

Federica Maccarinelli 1 collaboration

Fatlum Rruga 1 collaboration

Elena Mariotto 1 collaboration

Giampietro Viola 1 collaboration

Roberta Bortolozzi 1 collaboration

Hugues Cordel 1 collaboration

Claire Tantet 1 collaboration

Tatiana Stempak 1 collaboration

Eric Billaud 1 collaboration

Emilie Mosnier 1 collaboration

Florence Huber 1 collaboration

Sophie Florence 1 collaboration

Delphine Leclerc 1 collaboration

Anaeza Freire-Maresca 1 collaboration

Hélène de Champs Léger 1 collaboration

Marie Ahouanto 1 collaboration

François Linard 1 collaboration

Marie Petruzzi 1 collaboration

Emmanuelle Hamel 1 collaboration

Emmanuelle Le Lay 1 collaboration

Nathalie Lydié 1 collaboration

Anna Simon 1 collaboration

Leslie Alcouffe 1 collaboration

Nicolas Vignier 1 collaboration

Xin-Kang Tong 1 collaboration

Farhana Islam 1 collaboration

Arpit Doshi 1 collaboration

Andrew J Robles 1 collaboration

Tasdique M Quadery 1 collaboration

Xin Zhang 1 collaboration

Xilin Zhou 1 collaboration

Susan L Mooberry 1 collaboration

Aleem Gangjee 1 collaboration