Michela Puxeddu

Affiliations

Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185, Roma, Italy. Electronic address: michela.puxeddu@uniroma1.it.

Publications (17)

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

European journal of medicinal chemistry

Avec: Hongliang Shen , Ruoli Bai , Antonio Coluccia , Marianna Nalli , Carmela Mazzoccoli , Eleonora Da Pozzo , Chiara Cavallini , Claudia Martini , Viviana Orlando , Stefano Biagioni , Cristina Mazzoni , Addolorata Maria Luce Coluccia , Ernest Hamel , Te Liu , Romano Silvestri , Giuseppe La Regina

4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses.

ACS infectious diseases

Avec: Manuela Donalisio , Joachim Jakob Bugert , Angela Corona , Paolo Cocomazzi , Mario Milani , Friederike Hucke , Irene Arduino , Francesca Esposito , Paolo Moretti , Maria Grazia Ortore , Marianna Nalli , Simone Manetto , Giulia Mazzoccanti , Chiara Bigogno , Giulio Dondio , Pietro Sciò , Antonio Coluccia , Matteo Fracella , Guido Antonelli , David Lembo , Enzo Tramontano , Romano Silvestri , Eloise Mastrangelo , Giuseppe La Regina

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2.

Cells

Avec: Francesca Malagrinò , Antonio Coluccia , Marianna Bufano , Giuseppe La Regina , Angelo Toto , Lorenzo Visconti , Alessio Paone , Maria Chiara Magnifico , Francesca Troilo , Francesca Cutruzzolà , Romano Silvestri , Stefano Gianni

Sulfonamide Inhibitors of β-Catenin Signaling as Anticancer Agents with Different Output on c-MYC.

ChemMedChem

Avec: Laura Di Magno , Fiorella Di Pastena , Giuseppe La Regina , Antonio Coluccia , Alessia Ciogli , Simone Manetto , Marella Maroder , Gianluca Canettieri , Romano Silvestri , Marianna Nalli

Anticancer Activity of (

Cancers

Avec: Antonio Coluccia , Marianna Bufano , Giuseppe La Regina , Angelo Toto , Alessio Paone , Amani Bouzidi , Giorgia Musto , Nadia Badolati , Viviana Orlando , Stefano Biagioni , Domiziana Masci , Chiara Cantatore , Roberto Cirilli , Francesca Cutruzzolà , Stefano Gianni , Mariano Stornaiuolo , Romano Silvestri

4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1

Journal of medicinal chemistry

Avec: Domiziana Masci , Laura Di Magno , Michele D'Ambrosio , Anastasia Parisi , Marianna Nalli , Ruoli Bai , Antonio Coluccia , Pietro Sciò , Viviana Orlando , Sara D'Angelo , Stefano Biagioni , Andrea Urbani , Ernest Hamel , Alessio Nocentini , Serena Filiberti , Marta Turati , Roberto Ronca , Joanna Kopecka , Chiara Riganti , Cinzia Fionda , Rosa Bordone , Giorgia Della Rocca , Gianluca Canettieri , Claudiu T Supuran , Romano Silvestri , Giuseppe La Regina

Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.

Bioorganic chemistry

Avec: Marianna Bufano , Marianna Nalli , Giuseppe La Regina , Angelo Toto , Francesca Romana Liberati , Alessio Paone , Francesca Cutruzzolà , Domiziana Masci , Chiara Bigogno , Giulio Dondio , Romano Silvestri , Stefano Gianni , Antonio Coluccia

Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage.

ACS medicinal chemistry letters

Avec: Antonio Coluccia , Marianna Nalli , Chih-Ku Wei , Yu-Hsuan Wu , Eloise Mastrangelo , Tasneem Elamin , Delia Tarantino , Joachim Jakob Bugert , Benno Schreiner , Juliane Nolte , Frank Schwarze , Giuseppe La Regina , Jin-Ching Lee , Romano Silvestri

CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme.

European journal of pharmacology

Avec: Simona Daniele , Valeria La Pietra , Rebecca Piccarducci , Deborah Pietrobono , Chiara Cavallini , Vincenzo Maria D'Amore , Linda Cerofolini , Stefano Giuntini , Pasquale Russomanno , Marianna Nalli , Martina Pedrini , Marco Fragai , Claudio Luchinat , Ettore Novellino , Sabrina Taliani , Giuseppe La Regina , Romano Silvestri , Claudia Martini , Luciana Marinelli

Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance.

Pharmaceuticals (Basel, Switzerland)

Avec: Jana Van Dycke , Giuseppe La Regina , Eloise Mastrangelo , Delia Tarantino , Jasper Rymenants , Jessica Sebastiani , Marianna Nalli , Jelle Matthijnssens , Johan Neyts , Romano Silvestri , Joana Rocha-Pereira

Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy.

Molecules (Basel, Switzerland)

Avec: Domiziana Masci , Romano Silvestri , Giuseppe La Regina

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.

European journal of medicinal chemistry

Avec: Jessica Sebastiani , Marianna Nalli , Ruoli Bai , Ludovica Altieri , Paola Rovella , Eugenio Gaudio , Daniela Trisciuoglio , Filippo Spriano , Patrizia Lavia , Cinzia Fionda , Domiziana Masci , Andrea Urbani , Chiara Bigogno , Giulio Dondio , Ernest Hamel , Francesco Bertoni , Romano Silvestri , Giuseppe La Regina

Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment.

Molecules (Basel, Switzerland)

Avec: Domiziana Masci , Chiara Naro , Andrea Urbani , Claudio Sette , Giuseppe La Regina , Romano Silvestri

Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.

European journal of medicinal chemistry

Avec: Hongliang Shen , Ruoli Bai , Antonio Coluccia , Marianna Bufano , Marianna Nalli , Jessica Sebastiani , Diego Brancaccio , Eleonora Da Pozzo , Chiara Tremolanti , Claudia Martini , Viviana Orlando , Stefano Biagioni , Maria Stefania Sinicropi , Jessica Ceramella , Domenico Iacopetta , Addolorata Maria Luce Coluccia , Ernest Hamel , Te Liu , Romano Silvestri , Giuseppe La Regina

A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations.

Molecules (Basel, Switzerland)

Avec: Francesca Romana Mammone , Leo Zanitti , Giuseppe La Regina , Romano Silvestri , Anna Borioni , Roberto Cirilli

Targeting CBP and p300: Emerging Anticancer Agents.

Molecules (Basel, Switzerland)

Avec: Domiziana Masci , Romano Silvestri , Giuseppe La Regina

Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors.

ACS medicinal chemistry letters

Avec: Giuseppe La Regina , Marianna Nalli , Daniela Vullo , Paola Gratteri , Claudiu Trandafir Supuran , Alessio Nocentini , Romano Silvestri

Réseau de co-auteurs

Romano Silvestri 17 collaborations

Giuseppe La Regina 17 collaborations

Marianna Nalli 11 collaborations

Antonio Coluccia 9 collaborations

Domiziana Masci 7 collaborations

Ruoli Bai 4 collaborations

Viviana Orlando 4 collaborations

Stefano Biagioni 4 collaborations

Ernest Hamel 4 collaborations

Marianna Bufano 4 collaborations

Claudia Martini 3 collaborations

Chiara Bigogno 3 collaborations

Giulio Dondio 3 collaborations

Eloise Mastrangelo 3 collaborations

Angelo Toto 3 collaborations

Alessio Paone 3 collaborations

Francesca Cutruzzolà 3 collaborations

Stefano Gianni 3 collaborations

Andrea Urbani 3 collaborations

Jessica Sebastiani 3 collaborations

Hongliang Shen 2 collaborations

Eleonora Da Pozzo 2 collaborations

Chiara Cavallini 2 collaborations

Addolorata Maria Luce Coluccia 2 collaborations

Te Liu 2 collaborations

Joachim Jakob Bugert 2 collaborations

Simone Manetto 2 collaborations

Pietro Sciò 2 collaborations

Laura Di Magno 2 collaborations

Gianluca Canettieri 2 collaborations

Roberto Cirilli 2 collaborations

Alessio Nocentini 2 collaborations

Cinzia Fionda 2 collaborations

Delia Tarantino 2 collaborations

Carmela Mazzoccoli 1 collaboration

Cristina Mazzoni 1 collaboration

Manuela Donalisio 1 collaboration

Angela Corona 1 collaboration

Paolo Cocomazzi 1 collaboration

Mario Milani 1 collaboration

Friederike Hucke 1 collaboration

Irene Arduino 1 collaboration

Francesca Esposito 1 collaboration

Paolo Moretti 1 collaboration

Maria Grazia Ortore 1 collaboration

Giulia Mazzoccanti 1 collaboration

Matteo Fracella 1 collaboration

Guido Antonelli 1 collaboration

David Lembo 1 collaboration

Enzo Tramontano 1 collaboration

Francesca Malagrinò 1 collaboration

Lorenzo Visconti 1 collaboration

Maria Chiara Magnifico 1 collaboration

Francesca Troilo 1 collaboration

Fiorella Di Pastena 1 collaboration

Alessia Ciogli 1 collaboration

Marella Maroder 1 collaboration

Amani Bouzidi 1 collaboration

Giorgia Musto 1 collaboration

Nadia Badolati 1 collaboration

Chiara Cantatore 1 collaboration

Mariano Stornaiuolo 1 collaboration

Michele D'Ambrosio 1 collaboration

Anastasia Parisi 1 collaboration

Sara D'Angelo 1 collaboration

Serena Filiberti 1 collaboration

Marta Turati 1 collaboration

Roberto Ronca 1 collaboration

Joanna Kopecka 1 collaboration

Chiara Riganti 1 collaboration

Rosa Bordone 1 collaboration

Giorgia Della Rocca 1 collaboration

Claudiu T Supuran 1 collaboration

Francesca Romana Liberati 1 collaboration

Chih-Ku Wei 1 collaboration

Yu-Hsuan Wu 1 collaboration

Tasneem Elamin 1 collaboration

Benno Schreiner 1 collaboration

Juliane Nolte 1 collaboration

Frank Schwarze 1 collaboration

Jin-Ching Lee 1 collaboration

Simona Daniele 1 collaboration

Valeria La Pietra 1 collaboration

Rebecca Piccarducci 1 collaboration

Deborah Pietrobono 1 collaboration

Vincenzo Maria D'Amore 1 collaboration

Linda Cerofolini 1 collaboration

Stefano Giuntini 1 collaboration

Pasquale Russomanno 1 collaboration

Martina Pedrini 1 collaboration

Marco Fragai 1 collaboration

Claudio Luchinat 1 collaboration

Ettore Novellino 1 collaboration

Sabrina Taliani 1 collaboration

Luciana Marinelli 1 collaboration

Jana Van Dycke 1 collaboration

Jasper Rymenants 1 collaboration

Jelle Matthijnssens 1 collaboration

Johan Neyts 1 collaboration

Joana Rocha-Pereira 1 collaboration

Ludovica Altieri 1 collaboration

Paola Rovella 1 collaboration

Eugenio Gaudio 1 collaboration

Daniela Trisciuoglio 1 collaboration

Filippo Spriano 1 collaboration

Patrizia Lavia 1 collaboration

Francesco Bertoni 1 collaboration

Chiara Naro 1 collaboration

Claudio Sette 1 collaboration

Diego Brancaccio 1 collaboration

Chiara Tremolanti 1 collaboration

Maria Stefania Sinicropi 1 collaboration

Jessica Ceramella 1 collaboration

Domenico Iacopetta 1 collaboration

Francesca Romana Mammone 1 collaboration

Leo Zanitti 1 collaboration

Anna Borioni 1 collaboration

Daniela Vullo 1 collaboration

Paola Gratteri 1 collaboration

Claudiu Trandafir Supuran 1 collaboration