Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
received:
21
09
2019
accepted:
11
11
2019
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
22
5
2020
Statut:
epublish
Résumé
We report here the synthesis and human carbonic anhydrases (CA, EC 4.2.1.1) inhibitory properties of a series of 4'-substituted 1,1'-biphenyl-4-sulfonamides incorporating a 2″- or 3″-amino- or carboxyphenyl unit. Most compounds showed significant variations in their inhibition profiles against CA II and IX when compared to previously reported analogs
Identifiants
pubmed: 32435363
doi: 10.1021/acsmedchemlett.9b00437
pmc: PMC7236029
doi:
Types de publication
Journal Article
Langues
eng
Pagination
633-637Informations de copyright
Copyright © 2019 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Subcell Biochem. 2014;75:349-59
pubmed: 24146387
Chem Rev. 2012 Aug 8;112(8):4421-68
pubmed: 22607219
J Appl Physiol (1985). 2007 Apr;102(4):1305-7
pubmed: 17194729
Bioorg Med Chem. 2013 Mar 15;21(6):1377-8
pubmed: 23452985
Bioorg Med Chem. 2007 Jul 1;15(13):4336-50
pubmed: 17475500
Expert Opin Drug Discov. 2019 Nov;14(11):1175-1197
pubmed: 31436118
Nat Rev Drug Discov. 2008 Feb;7(2):168-81
pubmed: 18167490
Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77
pubmed: 21921921
JAMA. 2014 May 14;311(18):1901-11
pubmed: 24825645
Curr Pharm Des. 2008;14(7):649-54
pubmed: 18336310
J Biol Chem. 1971 Apr 25;246(8):2561-73
pubmed: 4994926
J Enzyme Inhib Med Chem. 2012 Dec;27(6):759-72
pubmed: 22468747
Bioorg Med Chem Lett. 2015 Apr 1;25(7):1385-9
pubmed: 25765908
J Med Chem. 2015 Nov 12;58(21):8564-72
pubmed: 26497049
Open Ophthalmol J. 2015 May 15;9:89-100
pubmed: 26069521
J Med Chem. 2011 Jun 9;54(11):3977-81
pubmed: 21506569