Ernest Hamel

Affiliations

Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, United States.

Publications (13)

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

European journal of medicinal chemistry

Avec: Michela Puxeddu , Hongliang Shen , Ruoli Bai , Antonio Coluccia , Marianna Nalli , Carmela Mazzoccoli , Eleonora Da Pozzo , Chiara Cavallini , Claudia Martini , Viviana Orlando , Stefano Biagioni , Cristina Mazzoni , Addolorata Maria Luce Coluccia , Ernest Hamel , Te Liu , Romano Silvestri , Giuseppe La Regina

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

ACS omega

Avec: Wolfgang Dohle , Andrea E Prota , Grégory Menchon , Ernest Hamel , Michel O Steinmetz , Barry V L Potter

How reliable is cerebral blood flow to map changes in neuronal activity?

Autonomic neuroscience : basic & clinical

Avec: Clotilde Lecrux , Miled Bourourou , Edith Hamel

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Melanie D Sweeney , Axel Montagne , Abhay P Sagare , Daniel A Nation , Lon S Schneider , Helena C Chui , Michael G Harrington , Judy Pa , Meng Law , Danny J J Wang , Russell E Jacobs , Fergus N Doubal , Joel Ramirez , Sandra E Black , Maiken Nedergaard , Helene Benveniste , Martin Dichgans , Costantino Iadecola , Seth Love , Philip M Bath , Hugh S Markus , Rustam Al-Shahi Salman , Stuart M Allan , Terence J Quinn , Rajesh N Kalaria , David J Werring , Roxana O Carare , Rhian M Touyz , Steve C R Williams , Michael A Moskowitz , Zvonimir S Katusic , Sarah E Lutz , Orly Lazarov , Richard D Minshall , Jalees Rehman , Thomas P Davis , Cheryl L Wellington , Hector M González , Chun Yuan , Samuel N Lockhart , Timothy M Hughes , Christopher L H Chen , Perminder Sachdev , John T O'Brien , Ingmar Skoog , Leonardo Pantoni , Deborah R Gustafson , Geert Jan Biessels , Anders Wallin , Eric E Smith , Vincent Mok , Adrian Wong , Peter Passmore , Frederick Barkof , Majon Muller , Monique M B Breteler , Gustavo C Román , Edith Hamel , Sudha Seshadri , Rebecca F Gottesman , Mark A van Buchem , Zoe Arvanitakis , Julie A Schneider , Lester R Drewes , Vladimir Hachinski , Caleb E Finch , Arthur W Toga , Joanna M Wardlaw , Berislav V Zlokovic

Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease.

Neurobiology of disease

Avec: Jessika Royea , Pauline Martinot , Edith Hamel

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.

Journal of natural products

Avec: Blake A Winn , Laxman Devkota , Bunnarack Kuch , Matthew T MacDonough , Tracy E Strecker , Yifan Wang , Zhe Shi , Jeni L Gerberich , Deboprosad Mondal , Alejandro J Ramirez , Ernest Hamel , David J Chaplin , Peter Davis , Ralph P Mason , Mary Lynn Trawick , Kevin G Pinney

New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action.

Bioorganic chemistry

Avec: Giuseppe Daidone , Antonella D'Anneo , Maria Valeria Raimondi , Demetrio Raffa , Ernest Hamel , Fabiana Plescia , Marianna Lauricella , Benedetta Maggio

A functional cerebral endothelium is necessary to protect against cognitive decline.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Avec: Lianne J Trigiani , Miled Bourourou , María Lacalle-Aurioles , Clotilde Lecrux , Amy Hynes , Shoshana Spring , Darren J Fernandes , John G Sled , Frédéric Lesage , Markus Schwaninger , Edith Hamel

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development.

Pharmacology & therapeutics

Avec: Mudasir Nabi Peerzada , Ernest Hamel , Ruoli Bai , Claudiu T Supuran , Amir Azam

A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents.

European journal of medicinal chemistry

Avec: Romeo Romagnoli , Paola Oliva , Maria Kimatrai Salvador , Stefano Manfredini , Chiara Padroni , Andrea Brancale , Salvatore Ferla , Ernest Hamel , Roberto Ronca , Federica Maccarinelli , Fatlum Rruga , Elena Mariotto , Giampietro Viola , Roberta Bortolozzi

Addressing sexuality and sexual health with migrants. Practice guidelines.

Infectious diseases now

Avec: Hugues Cordel , Claire Tantet , Tatiana Stempak , Eric Billaud , Emilie Mosnier , Florence Huber , Sophie Florence , Delphine Leclerc , Anaeza Freire-Maresca , Hélène de Champs Léger , Marie Ahouanto , François Linard , Marie Petruzzi , Emmanuelle Hamel , Emmanuelle Le Lay , Nathalie Lydié , Anna Simon , Leslie Alcouffe , Nicolas Vignier

Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.

Cell death & disease

Avec: Xin-Kang Tong , Jessika Royea , Edith Hamel

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-

Molecules (Basel, Switzerland)

Avec: Farhana Islam , Arpit Doshi , Andrew J Robles , Tasdique M Quadery , Xin Zhang , Xilin Zhou , Ernest Hamel , Susan L Mooberry , Aleem Gangjee

Réseau de co-auteurs

Edith Hamel 5 collaborations

Ruoli Bai 2 collaborations

Clotilde Lecrux 2 collaborations

Miled Bourourou 2 collaborations

Jessika Royea 2 collaborations

Michela Puxeddu 1 collaboration

Hongliang Shen 1 collaboration

Antonio Coluccia 1 collaboration

Marianna Nalli 1 collaboration

Carmela Mazzoccoli 1 collaboration

Eleonora Da Pozzo 1 collaboration

Chiara Cavallini 1 collaboration

Claudia Martini 1 collaboration

Viviana Orlando 1 collaboration

Stefano Biagioni 1 collaboration

Cristina Mazzoni 1 collaboration

Addolorata Maria Luce Coluccia 1 collaboration

Te Liu 1 collaboration

Romano Silvestri 1 collaboration

Giuseppe La Regina 1 collaboration

Wolfgang Dohle 1 collaboration

Andrea E Prota 1 collaboration

Grégory Menchon 1 collaboration

Michel O Steinmetz 1 collaboration

Barry V L Potter 1 collaboration

Melanie D Sweeney 1 collaboration

Axel Montagne 1 collaboration

Abhay P Sagare 1 collaboration

Daniel A Nation 1 collaboration

Lon S Schneider 1 collaboration

Helena C Chui 1 collaboration

Michael G Harrington 1 collaboration

Judy Pa 1 collaboration

Meng Law 1 collaboration

Danny J J Wang 1 collaboration

Russell E Jacobs 1 collaboration

Fergus N Doubal 1 collaboration

Joel Ramirez 1 collaboration

Sandra E Black 1 collaboration

Maiken Nedergaard 1 collaboration

Helene Benveniste 1 collaboration

Martin Dichgans 1 collaboration

Costantino Iadecola 1 collaboration

Seth Love 1 collaboration

Philip M Bath 1 collaboration

Hugh S Markus 1 collaboration

Rustam Al-Shahi Salman 1 collaboration

Stuart M Allan 1 collaboration

Terence J Quinn 1 collaboration

Rajesh N Kalaria 1 collaboration

David J Werring 1 collaboration

Roxana O Carare 1 collaboration

Rhian M Touyz 1 collaboration

Steve C R Williams 1 collaboration

Michael A Moskowitz 1 collaboration

Zvonimir S Katusic 1 collaboration

Sarah E Lutz 1 collaboration

Orly Lazarov 1 collaboration

Richard D Minshall 1 collaboration

Jalees Rehman 1 collaboration

Thomas P Davis 1 collaboration

Cheryl L Wellington 1 collaboration

Hector M González 1 collaboration

Chun Yuan 1 collaboration

Samuel N Lockhart 1 collaboration

Timothy M Hughes 1 collaboration

Christopher L H Chen 1 collaboration

Perminder Sachdev 1 collaboration

John T O'Brien 1 collaboration

Ingmar Skoog 1 collaboration

Leonardo Pantoni 1 collaboration

Deborah R Gustafson 1 collaboration

Geert Jan Biessels 1 collaboration

Anders Wallin 1 collaboration

Eric E Smith 1 collaboration

Vincent Mok 1 collaboration

Adrian Wong 1 collaboration

Peter Passmore 1 collaboration

Frederick Barkof 1 collaboration

Majon Muller 1 collaboration

Monique M B Breteler 1 collaboration

Gustavo C Román 1 collaboration

Sudha Seshadri 1 collaboration

Rebecca F Gottesman 1 collaboration

Mark A van Buchem 1 collaboration

Zoe Arvanitakis 1 collaboration

Julie A Schneider 1 collaboration

Lester R Drewes 1 collaboration

Vladimir Hachinski 1 collaboration

Caleb E Finch 1 collaboration

Arthur W Toga 1 collaboration

Joanna M Wardlaw 1 collaboration

Berislav V Zlokovic 1 collaboration

Pauline Martinot 1 collaboration

Blake A Winn 1 collaboration

Laxman Devkota 1 collaboration

Bunnarack Kuch 1 collaboration

Matthew T MacDonough 1 collaboration

Tracy E Strecker 1 collaboration

Yifan Wang 1 collaboration

Zhe Shi 1 collaboration

Jeni L Gerberich 1 collaboration

Deboprosad Mondal 1 collaboration

Alejandro J Ramirez 1 collaboration

David J Chaplin 1 collaboration

Peter Davis 1 collaboration

Ralph P Mason 1 collaboration

Mary Lynn Trawick 1 collaboration

Kevin G Pinney 1 collaboration

Giuseppe Daidone 1 collaboration

Antonella D'Anneo 1 collaboration

Maria Valeria Raimondi 1 collaboration

Demetrio Raffa 1 collaboration

Fabiana Plescia 1 collaboration

Marianna Lauricella 1 collaboration

Benedetta Maggio 1 collaboration

Lianne J Trigiani 1 collaboration

María Lacalle-Aurioles 1 collaboration

Amy Hynes 1 collaboration

Shoshana Spring 1 collaboration

Darren J Fernandes 1 collaboration

John G Sled 1 collaboration

Frédéric Lesage 1 collaboration

Markus Schwaninger 1 collaboration

Mudasir Nabi Peerzada 1 collaboration

Claudiu T Supuran 1 collaboration

Amir Azam 1 collaboration

Romeo Romagnoli 1 collaboration

Paola Oliva 1 collaboration

Maria Kimatrai Salvador 1 collaboration

Stefano Manfredini 1 collaboration

Chiara Padroni 1 collaboration

Andrea Brancale 1 collaboration

Salvatore Ferla 1 collaboration

Roberto Ronca 1 collaboration

Federica Maccarinelli 1 collaboration

Fatlum Rruga 1 collaboration

Elena Mariotto 1 collaboration

Giampietro Viola 1 collaboration

Roberta Bortolozzi 1 collaboration

Hugues Cordel 1 collaboration

Claire Tantet 1 collaboration

Tatiana Stempak 1 collaboration

Eric Billaud 1 collaboration

Emilie Mosnier 1 collaboration

Florence Huber 1 collaboration

Sophie Florence 1 collaboration

Delphine Leclerc 1 collaboration

Anaeza Freire-Maresca 1 collaboration

Hélène de Champs Léger 1 collaboration

Marie Ahouanto 1 collaboration

François Linard 1 collaboration

Marie Petruzzi 1 collaboration

Emmanuelle Hamel 1 collaboration

Emmanuelle Le Lay 1 collaboration

Nathalie Lydié 1 collaboration

Anna Simon 1 collaboration

Leslie Alcouffe 1 collaboration

Nicolas Vignier 1 collaboration

Xin-Kang Tong 1 collaboration

Farhana Islam 1 collaboration

Arpit Doshi 1 collaboration

Andrew J Robles 1 collaboration

Tasdique M Quadery 1 collaboration

Xin Zhang 1 collaboration

Xilin Zhou 1 collaboration

Susan L Mooberry 1 collaboration

Aleem Gangjee 1 collaboration