New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action.
Antiproliferative activity
Apoptosis
Autophagy
MDA-MB231 breast cancer cells
O-glycoconjugate polycyclic compounds
Pyrazolo[3,4-b]pyrazolo[3′,4′:2,3]azepino[4,5-f]azocine
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
18
02
2020
revised:
25
04
2020
accepted:
29
05
2020
pubmed:
21
6
2020
medline:
30
3
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
Polycyclic or O-glycoconiugate polycyclic compounds 1a-g were previously tested for their in vitro antiproliferative activity. In this series of compounds, activity increases as log P decreases. Specifically, compounds 1d and 1g showed lower log P values together with the best antiproliferative profiles. With the aim of extending our understanding of the structure-activity relationship (SAR) of this class of compounds, we prepared new polycyclic derivatives 2a-c, which bear on each of the two phenyl rings hydrophilic substituents (OH, SO
Identifiants
pubmed: 32563004
pii: S0045-2068(20)31286-4
doi: 10.1016/j.bioorg.2020.103989
pii:
doi:
Substances chimiques
Polycyclic Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
103989Subventions
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.