A functional cerebral endothelium is necessary to protect against cognitive decline.
Animals
Blood Flow Velocity
Brain
/ blood supply
Cerebrovascular Circulation
Cognitive Dysfunction
/ genetics
Endothelium, Vascular
/ metabolism
Female
Interneurons
/ metabolism
Intracellular Signaling Peptides and Proteins
/ deficiency
Male
Mice
Mice, Knockout
Somatostatin
/ metabolism
Vasodilation
Cerebral endothelium
NF-κB essential modulator
physical exercise
simvastatin
vascular cognitive impairment
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
14
9
2021
medline:
9
2
2022
entrez:
13
9
2021
Statut:
ppublish
Résumé
A vascular insult occurring early in disease onset may initiate cognitive decline leading to dementia, while pharmacological and lifestyle interventions can prevent this progression. Mice with a selective, tamoxifen-inducible deletion of NF-κB essential modulator (Nemo) in brain endothelial cells were studied as a model of vascular cognitive impairment. Groups included Nemo
Identifiants
pubmed: 34515549
doi: 10.1177/0271678X211045438
pmc: PMC8721775
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
NEMO protein, mouse
0
Somatostatin
51110-01-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-89Subventions
Organisme : CIHR
ID : MOP-126001
Pays : Canada
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