Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-

Cell Line, Tumor Cell Proliferation / drug effects Chemistry Techniques, Synthetic Drug Design Drug Resistance, Neoplasm Humans Models, Molecular Molecular Conformation Molecular Structure Protein Multimerization / drug effects Pyrimidines / chemical synthesis Structure-Activity Relationship Tubulin / chemistry Tubulin Modulators / chemical synthesis
Gewald reaction colchicine site microtubule targeting agents microtubules

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
05 Jan 2022
Historique:
received: 07 10 2021
revised: 21 12 2021
accepted: 22 12 2021
entrez: 11 1 2022
pubmed: 12 1 2022
medline: 10 2 2022
Statut: epublish

Résumé

A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-

Identifiants

DOI: 10.3390/molecules27010321 PMID: 35011550 PMC: PMC8747035
pubmed: 35011550
pii: molecules27010321
doi: 10.3390/molecules27010321
pmc: PMC8747035
pii:
doi:

Substances chimiques

Pyrimidines 0
Tubulin 0
Tubulin Modulators 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NCI NIH HHS
ID : CA142868
Pays : United States

Références

Clin Cancer Res. 2015 Jun 1;21(11):2445-52
pubmed: 25838395
Curr Med Chem. 2015;22(11):1348-60
pubmed: 25620094
Mol Cancer Ther. 2009 Aug;8(8):2086-95
pubmed: 19671735
Bioorg Med Chem. 2013 Feb 15;21(4):891-902
pubmed: 23332369
Bioorg Med Chem. 2021 Jan 1;29:115887
pubmed: 33310545
Nat Rev Drug Discov. 2010 Oct;9(10):790-803
pubmed: 20885410
Bioorg Chem. 2019 Sep;90:103077
pubmed: 31323598
Molecules. 2010 Jun 01;15(6):3932-57
pubmed: 20657418
Clin Cancer Res. 2000 Sep;6(9):3459-68
pubmed: 10999729
Int J Biochem Cell Biol. 2012 Feb;44(2):266-74
pubmed: 22108200
Molecules. 2017 Aug 01;22(8):
pubmed: 28763044
J Comb Chem. 2008 Nov-Dec;10(6):858-62
pubmed: 18767818
J Nat Prod. 2019 Mar 22;82(3):680-685
pubmed: 30835122
ACS Med Chem Lett. 2014 Feb 27;5(5):480-4
pubmed: 24900865
Br J Cancer. 2010 Jan 19;102(2):316-24
pubmed: 20029418
Eur J Med Chem. 2010 Jun;45(6):2473-9
pubmed: 20219270
Anticancer Res. 2007 May-Jun;27(3B):1509-18
pubmed: 17595769
J Chem Theory Comput. 2006 May;2(3):863-72
pubmed: 26626693
Bioorg Med Chem Lett. 2017 Aug 1;27(15):3423-3430
pubmed: 28610978
Bioorg Med Chem. 2020 Jun 15;28(12):115544
pubmed: 32503687
Bioorg Med Chem. 2013 Sep 1;21(17):4976-87
pubmed: 23886813
Mol Pharmacol. 1998 Jan;53(1):62-76
pubmed: 9443933
Nat Prod Rep. 2014 Mar;31(3):335-55
pubmed: 24481420
Cancer Res. 2008 Nov 1;68(21):8881-8
pubmed: 18974132
J Med Chem. 2018 Feb 22;61(4):1704-1718
pubmed: 29406710
Immunol Res. 2021 Aug;69(4):378-390
pubmed: 34219199
Biochemistry. 1984 Aug 28;23(18):4173-84
pubmed: 6487596
Pharm Res. 2012 Nov;29(11):2943-71
pubmed: 22814904
Bioorg Med Chem. 2018 May 15;26(9):2437-2451
pubmed: 29655610
Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):
pubmed: 33619102
Curr Drug Targets. 2021;22(17):1944-1963
pubmed: 34042033
J Med Chem. 2010 Jan 14;53(1):325-34
pubmed: 19894742
Cell Biochem Biophys. 2003;38(1):1-22
pubmed: 12663938
Bioorg Med Chem. 2014 Sep 15;22(18):5050-9
pubmed: 24650703
BMC Cancer. 2015 Jul 23;15:536
pubmed: 26198101
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21
pubmed: 25114240
Chem Biol. 2012 Jun 22;19(6):686-98
pubmed: 22726683
Trends Cell Biol. 2018 Oct;28(10):776-792
pubmed: 29871823
Bioorg Med Chem Lett. 2021 Jun 1;41:127923
pubmed: 33705908
Cochrane Database Syst Rev. 2014 Aug 15;(8):CD006190
pubmed: 25123076
RSC Med Chem. 2021 May 18;12(6):970-981
pubmed: 34223162
Mol Cancer Ther. 2015 Jan;14(1):193-201
pubmed: 25416788
J Natl Cancer Inst. 1990 Jul 4;82(13):1107-12
pubmed: 2359136
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1641-1656
pubmed: 32781854
Bioorg Chem. 2019 Jul;88:102944
pubmed: 31051400
Nat Prod Rep. 2016 Apr;33(4):549-61
pubmed: 26867978
Nat Rev Cancer. 2004 Apr;4(4):253-65
pubmed: 15057285
Prog Chem Org Nat Prod. 2020;112:183-206
pubmed: 33306174
Pharmaceuticals (Basel). 2020 Apr 20;13(4):
pubmed: 32325955
J Mol Biol. 2016 Jul 31;428(15):2981-8
pubmed: 27395016
Drug Discov Today. 2011 Feb;16(3-4):164-71
pubmed: 21129497

Auteurs

Farhana Islam (F)

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Arpit Doshi (A)

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Andrew J Robles (AJ)

Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Mays Cancer Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

Tasdique M Quadery (TM)

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Xin Zhang (X)

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Xilin Zhou (X)

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Ernest Hamel (E)

Molecular Pharmacology Branch, Developmental Therapeutics Program, Frederick National Laboratory for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Susan L Mooberry (SL)

Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Mays Cancer Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
ORCID: 0000-0001-8575-2516

Aleem Gangjee (A)

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Modulateurs de la mitose › Modulateurs de la polymérisation de la tubuline › Design, Synthesis, and Biological Evaluation...