Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence.
adolescent substance use
cannabis
cognition
marijuana
psychopathology
voxel-based morphometry
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
06 03 2019
06 03 2019
Historique:
received:
01
12
2017
revised:
03
12
2018
accepted:
11
12
2018
pubmed:
16
1
2019
medline:
24
3
2020
entrez:
16
1
2019
Statut:
ppublish
Résumé
Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human adolescents (males and females) with just one or two instances of cannabis use and carefully matched THC-naive controls. We identified extensive regions in the bilateral medial temporal lobes as well as the bilateral posterior cingulate, lingual gyri, and cerebellum that showed greater GMV in the cannabis users. Analysis of longitudinal data confirmed that GMV differences were unlikely to precede cannabis use. GMV in the temporal regions was associated with contemporaneous performance on the Perceptual Reasoning Index and with future generalized anxiety symptoms in the cannabis users. The distribution of GMV effects mapped onto biomarkers of the endogenous cannabinoid system providing insight into possible mechanisms for these effects.
Identifiants
pubmed: 30643026
pii: JNEUROSCI.3375-17.2018
doi: 10.1523/JNEUROSCI.3375-17.2018
pmc: PMC6407302
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1817-1827Subventions
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2019 the authors 0270-6474/19/391818-11$15.00/0.
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