Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity.

Adjuvants, Immunologic / chemistry Animals Antigens, Protozoan / chemistry Glycoconjugates / chemistry Immunity, Cellular / drug effects Immunity, Humoral / drug effects Mice Plasmodium falciparum / immunology Polymers / chemistry Protozoan Vaccines / chemistry

Journal

Nature materials
ISSN: 1476-4660
Titre abrégé: Nat Mater
Pays: England
ID NLM: 101155473

Informations de publication

Date de publication:
02 2019
Historique:
received: 31 10 2017
accepted: 20 11 2018
pubmed: 16 1 2019
medline: 11 5 2019
entrez: 16 1 2019
Statut: ppublish

Résumé

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8

Identifiants

DOI: 10.1038/s41563-018-0256-5 PMID: 30643235
pubmed: 30643235
doi: 10.1038/s41563-018-0256-5
pii: 10.1038/s41563-018-0256-5
doi:

Substances chimiques

Adjuvants, Immunologic 0
Antigens, Protozoan 0
Glycoconjugates 0
Polymers 0
Protozoan Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

175-185

Commentaires et corrections

Type : CommentIn

Auteurs

D Scott Wilson (DS)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA.

Sachiko Hirosue (S)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Michal M Raczy (MM)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA.

Leonardo Bonilla-Ramirez (L)

Sorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI, Paris, France.

Laura Jeanbart (L)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Ruyi Wang (R)

Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA.

Marcin Kwissa (M)

Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA.

Jean-Francois Franetich (JF)

Sorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI, Paris, France.

Maria A S Broggi (MAS)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA.

Giacomo Diaceri (G)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Xavier Quaglia-Thermes (X)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Dominique Mazier (D)

Sorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI, Paris, France.

Melody A Swartz (MA)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA.

Jeffrey A Hubbell (JA)

Institute for Bioengineering, School of Life Science and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. jhubbell@uchicago.edu.
Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.
ORCID: 0000-0003-0276-5456

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Adjuvants immunologiques › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Eucaryotes › Animaux › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de protozoaire › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Glucides › Glycoconjugués › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité humorale › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Antigens reversibly conjugated to a polymeric...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiprotozoaires › Antigens reversibly conjugated to a polymeric...