Dimensional structure of first episode psychosis.
Adult
Cluster Analysis
Delusions
/ complications
Depression
/ complications
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Italy
Male
Psychiatric Status Rating Scales
/ statistics & numerical data
Psychotic Disorders
/ complications
Randomized Controlled Trials as Topic
/ statistics & numerical data
Young Adult
affective symptoms
dimension
first episode psychosis
negative symptoms
positive symptoms
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
15
03
2017
revised:
13
02
2018
accepted:
26
12
2018
pubmed:
16
1
2019
medline:
10
3
2020
entrez:
16
1
2019
Statut:
ppublish
Résumé
Current diagnostic systems, DSM-5 and ICD-10, still adopt a categorical approach to classify psychotic disorders. The present study was aimed at investigating the structure of psychotic symptomatology in both affective and non-affective psychosis from a dimensional approach. Participants with a first episode psychosis (FEP) were recruited from a cluster-randomized controlled trial (GET-UP PIANO TRIAL), offered to all Community Mental Health Centres (CMHCs) located across two northern Italian regions. After clinical stabilization, patients were assessed with a comprehensive set of psychopathological measures including the Positive and Negative Syndrome Scale, the Hamilton Depression Rating Scale and the Bech-Rafaelsen Mania Rating Scale. A two-step cluster analysis was performed. Overall, 257 FEP patients (male, n = 171, 66.5%; mean age = 24.96 ± 4.56) were included in the study. The cluster analysis revealed a robust four-cluster solution: delusional-persecutory (n = 82; 31.9%), depressed (n = 95; 37%), excited (n = 26; 10.1%) and negative-disorganized (n = 54; 21%), thus suggesting a quadripartite structure with both affective and non-affective dimensions. Among non-affective dimensions, negative and disorganization symptoms constituted a unique construct apart from positive symptoms. Symptom dimensions may represent a useful tool for dissecting the indistinct and non-specific psychopathology of FEP in order to better target specific interventions.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1431-1438Subventions
Organisme : Italian Ministry of Health
ID : H61J08000200001
Pays : International
Informations de copyright
© 2019 John Wiley & Sons Australia, Ltd.
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