Extracellular CIRP (eCIRP) and inflammation.
ALI
CIRP
DAMP
eCIRP
hemorrhage
inflammation
ischemia/reperfusion
macrophage
neutrophils
sepsis
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
19
11
2018
revised:
27
12
2018
accepted:
30
12
2018
pubmed:
16
1
2019
medline:
12
5
2020
entrez:
16
1
2019
Statut:
ppublish
Résumé
Cold-inducible RNA-binding protein (CIRP) was discovered 2 decades ago while studying the mechanism of cold stress adaptation in mammals. Since then, the role of intracellular CIRP (iCIRP) as a stress-response protein has been extensively studied. Recently, extracellular CIRP (eCIRP) was discovered to also have an important role, acting as a damage-associated molecular pattern, raising critical implications for the pathobiology of inflammatory diseases. During hemorrhagic shock and sepsis, inflammation triggers the translocation of CIRP from the nucleus to the cytosol and its release to the extracellular space. eCIRP then induces inflammatory responses in macrophages, neutrophils, lymphocytes, and dendritic cells. eCIRP also induces endoplasmic reticulum stress and pyroptosis in endothelial cells by activating the NF-κB and inflammasome pathways, and necroptosis in macrophages via mitochondrial DNA damage. eCIRP works through the TLR4-MD2 receptors. Studies with CIRP
Identifiants
pubmed: 30645013
doi: 10.1002/JLB.3MIR1118-443R
pmc: PMC6597266
mid: NIHMS1004674
doi:
Substances chimiques
Alarmins
0
CIRBP protein, human
0
Inflammation Mediators
0
RNA-Binding Proteins
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-146Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL076179
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM129633
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118337
Pays : United States
Informations de copyright
©2019 Society for Leukocyte Biology.
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