Megakaryocytes as immune cells.
IL-1
inflammation
lung
microparticle
platelets
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
30
08
2018
revised:
26
11
2018
accepted:
26
11
2018
pubmed:
16
1
2019
medline:
6
5
2020
entrez:
16
1
2019
Statut:
ppublish
Résumé
Platelets play well-recognized roles in inflammation, but their cell of origin-the megakaryocyte-is not typically considered an immune lineage. Megakaryocytes are large polyploid cells most commonly identified in bone marrow. Egress via sinusoids enables migration to the pulmonary capillary bed, where elaboration of platelets can continue. Beyond receptors involved in hemostasis and thrombosis, megakaryocytes express receptors that confer immune sensing capacity, including TLRs and Fc-γ receptors. They control the proliferation of hematopoietic cells, facilitate neutrophil egress from marrow, possess the capacity to cross-present antigen, and can promote systemic inflammation through microparticles rich in IL-1. Megakaryocytes internalize other hematopoietic lineages, especially neutrophils, in an intriguing cell-in-cell interaction termed emperipolesis. Together, these observations implicate megakaryocytes as direct participants in inflammation and immunity.
Identifiants
pubmed: 30645026
doi: 10.1002/JLB.MR0718-261RR
pmc: PMC6984013
mid: NIHMS1066731
doi:
Substances chimiques
Interleukin-1
0
Receptors, IgG
0
Toll-Like Receptors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1111-1121Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR070253
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065538
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075906
Pays : United States
Informations de copyright
©2019 Society for Leukocyte Biology.
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