Titre : Mégacaryocytes

Mégacaryocytes : Questions médicales fréquentes

Questions fréquentes et termes MeSH associés

Général 1

#1

Erreur lors de la génération.

Veuillez réessayer ultérieurement.
Megakaryocytes
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Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 15/07/2026

Contenu vérifié selon les dernières recommandations médicales

Auteurs principaux

Eric Boilard

3 publications dans cette catégorie

Affiliations :
  • Department of Infectious Diseases and Immunity, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Canada (F.P., A.L., E.B.).
  • Centre de Recherche ARThrite, Faculté de Médecine de l'Université Laval, Québec, Canada (F.P., A.L., E.B.).
Publications dans "Mégacaryocytes" :

Diane S Krause

3 publications dans cette catégorie

Affiliations :
  • Yale University School of Medicine, New Haven, Connecticut, United States.

John D Crispino

3 publications dans cette catégorie

Affiliations :
  • Northwestern University, Division of Hematology/Oncology, Chicago, Illinois 60611, USA.
Publications dans "Mégacaryocytes" :

Hongtao Wang

3 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; CAMS Center for Stem Cell Medicine, PUMC Department of Stem Cell and Regenerative Medicine, Tianjin 300020, China.
Publications dans "Mégacaryocytes" :

Cuicui Liu

3 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; CAMS Center for Stem Cell Medicine, PUMC Department of Stem Cell and Regenerative Medicine, Tianjin 300020, China.
Publications dans "Mégacaryocytes" :

Jiaxi Zhou

3 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; CAMS Center for Stem Cell Medicine, PUMC Department of Stem Cell and Regenerative Medicine, Tianjin 300020, China. Electronic address: zhoujx@ihcams.ac.cn.
Publications dans "Mégacaryocytes" :

Katya Ravid

3 publications dans cette catégorie

Affiliations :
  • Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA. Electronic address: kravid@bu.edu.

Alison C Livada

3 publications dans cette catégorie

Affiliations :
  • Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Publications dans "Mégacaryocytes" :

Craig N Morrell

3 publications dans cette catégorie

Affiliations :
  • Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Publications dans "Mégacaryocytes" :

Kellie R Machlus

3 publications dans cette catégorie

Affiliations :
  • Vascular Biology Program, Boston Children's Hospital.
  • Harvard Medical School, Boston, Massachusetts, USA.
Publications dans "Mégacaryocytes" :

Audrée Laroche

2 publications dans cette catégorie

Affiliations :
  • Department of Infectious Diseases and Immunity, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Canada (F.P., A.L., E.B.).
  • Centre de Recherche ARThrite, Faculté de Médecine de l'Université Laval, Québec, Canada (F.P., A.L., E.B.).
Publications dans "Mégacaryocytes" :

Nayoung Kwon

2 publications dans cette catégorie

Affiliations :
  • Yale University, New Haven, Connecticut, United States.

Yi-Chien Lu

2 publications dans cette catégorie

Affiliations :
  • Yale University School of Medicine, New Haven, Connecticut, United States.

Evrett N Thompson

2 publications dans cette catégorie

Affiliations :
  • Yale University Department of Cell Biology, New Haven, Connecticut, United States.

Ping-Xia Zhang

2 publications dans cette catégorie

Affiliations :
  • yale university, new haven, Connecticut, United States.

David Stegner

2 publications dans cette catégorie

Affiliations :
  • Institute of Experimental Biomedicine, University Hospital Würzburg , Würzburg, Germany.
Publications dans "Mégacaryocytes" :

Pierre Cunin

2 publications dans cette catégorie

Affiliations :
  • Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Publications dans "Mégacaryocytes" :

Peter A Nigrovic

2 publications dans cette catégorie

Affiliations :
  • Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Department of Medicine, Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Publications dans "Mégacaryocytes" :

Sanjeev Raghuwanshi

2 publications dans cette catégorie

Affiliations :
  • Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad , Hyderabad , TS , India.
Publications dans "Mégacaryocytes" :

Ravi Kumar Gutti

2 publications dans cette catégorie

Affiliations :
  • Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad , Hyderabad , TS , India.
Publications dans "Mégacaryocytes" :

Sources (73 au total)

The many faces of the megakaryocytes and their biological implications.

Single-cell RNA sequencing studies have revealed transcriptional heterogeneity within the megakaryocytic lineage and the identified unique subsets. In this review, we discuss the functional and phenot... Megakaryocytes (MKs) can be transcriptionally categorized into platelet generating, niche supporting, immune, and cycling cells, which are distinguished by their unique gene expression patterns and ce... Advances in megakaryocyte research has elucidated the existence of multiple subpopulations of MKs that serve different functions. These subpopulations implicate a greater potential for MKs to be regul...

FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation.

Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized by thrombocytopenia, pl...

An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation.

During hematopoiesis, megakaryocytic erythroid progenitors (MEPs) differentiate into megakaryocytic or erythroid lineages in response to specific transcriptional factors, yet the regulatory mechanism ...

The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism.

Patients with COVID-19 have coagulation and platelet disorders, with platelet alterations and thrombocytopenia representing negative prognostic parameters associated with severe forms of the disease a... The aim of this study was to study the expression of platelet glycoprotein IIIa (CD61), playing a critical role in platelet aggregation, together with TRL-2 as a marker of innate immune activation.... A total of 25 patients were investigated, with the majority (24/25, 96%) having co-morbidities and dying from a fatal form of SARS-CoV-2(+) infection (COVID-19+), with 13 men and 12 females ranging in... Microthrombosis in deadly COVID-19+ lung disease is associated with an increase in the number of CD61+ platelets and megakaryocytes in the pulmonary interstitium, as well as their functional activatio...