The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.
Animals
Arthritis
/ genetics
Dendritic Cells
/ metabolism
Inflammation
/ genetics
Lipopolysaccharides
/ metabolism
Mice, Inbred C57BL
Mice, Knockout
Neutrophils
/ metabolism
Nitric Oxide
/ metabolism
Protein Binding
Receptors, Immunologic
/ genetics
Signal Transduction
/ drug effects
Sphingosine
/ analogs & derivatives
Toll-Like Receptor 4
/ metabolism
Zymosan
/ metabolism
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
entrez:
17
1
2019
pubmed:
17
1
2019
medline:
24
3
2020
Statut:
epublish
Résumé
Zymosan is a glucan that is a component of the yeast cell wall. Here, we determined the mechanisms underlying the zymosan-induced accumulation of neutrophils in mice. Loss of the receptor CD300b reduced the number of neutrophils recruited to dorsal air pouches in response to zymosan, but not in response to lipopolysaccharide (LPS), a bacterial membrane component recognized by Toll-like receptor 4 (TLR4). An inhibitor of nitric oxide (NO) synthesis reduced the number of neutrophils in the zymosan-treated air pouches of wild-type mice to an amount comparable to that in
Identifiants
pubmed: 30647146
pii: 12/564/eaar5514
doi: 10.1126/scisignal.aar5514
pii:
doi:
Substances chimiques
LMIR5 protein, mouse
0
Lipopolysaccharides
0
Receptors, Immunologic
0
Toll-Like Receptor 4
0
Nitric Oxide
31C4KY9ESH
Zymosan
9010-72-4
phytosphingosine
GIN46U9Q2Q
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.