A comprehensive catalog of LncRNAs expressed in T-cell acute lymphoblastic leukemia.
Cell Line, Tumor
Cell Transformation, Neoplastic
/ genetics
Epigenesis, Genetic
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Oncogenes
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/ genetics
RNA, Long Noncoding
/ genetics
Reproducibility of Results
Thymus Gland
/ immunology
Large non-coding RNA
LncRNA
T-ALL
T-cell acute leukemia
oncogenes
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
17
1
2019
medline:
12
8
2020
entrez:
17
1
2019
Statut:
ppublish
Résumé
Several studies have demonstrated that LncRNAs can play major roles in cancer development. The creation of a catalog of LncRNAs expressed in T cell acute lymphoblastic leukemia (T-ALL) is thus of particular importance. However, this task is challenging as LncRNA expression is highly restricted in time and space manner and thus may greatly differ between samples. We performed a systematic transcript discovery in RNA-Seq data obtained from T-ALL primary cells and cell lines. This led to the identification of 2560 novel LncRNAs. After the integration of these transcripts into a large compendium of LncRNAs (
Identifiants
pubmed: 30648438
doi: 10.1080/10428194.2018.1551534
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM