Rapid screening of sulfonamides in dietary supplements based on extracted common ion chromatogram and neutral loss scan by LC-Q/TOF-mass spectrometry.
Dietary supplements
Extracted common ion chromatogram
Neutral loss scan
Sulfonamides
UHPLC-Q/TOF-MS
Journal
Journal of food and drug analysis
ISSN: 2224-6614
Titre abrégé: J Food Drug Anal
Pays: China (Republic : 1949- )
ID NLM: 101630927
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
15
05
2018
revised:
01
08
2018
accepted:
13
08
2018
entrez:
17
1
2019
pubmed:
17
1
2019
medline:
24
3
2020
Statut:
ppublish
Résumé
There is an increasing amount of dietary supplements that are adulterated with diuretics and anti-diabetic drugs; this has become a global problem due to the wide distribution of dietary supplements and the serious negative health effects of the adulterants. In this study, a rapid screening method was developed for detection and confirmation of 35 sulfonamides in supplements by ultra-high performance liquid chromatography quadrupole/time of flight mass spectrometry. For effective extraction of sulfonamides from dietary supplements, four extraction protocols including HLB and WAX solid-phase extraction, Quick Easy Cheap Effective Rugged and Safe method, and pH-controlled liquid-liquid extraction were evaluated, and pH-controlled liquid-liquid extraction method was shown to be the most effective with high recovery efficiency and low matrix effect. Rapid separation of 35 sulfonamides was achieved with the UHPLC C18 column (150 × 2.1 mm, 1.7 um) within 7 min using ammonium acetate aqueous solution (pH 8) and acetonitrile as the mobile phase. From the MS/MS spectra of sulfonamides, common ions (m/z 77.9650 [SO
Identifiants
pubmed: 30648569
pii: j.jfda.2018.08.006
doi: 10.1016/j.jfda.2018.08.006
pmc: PMC9298626
doi:
Substances chimiques
Diuretics
0
Hypoglycemic Agents
0
Sulfonamides
0
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
164-174Informations de copyright
Copyright © 2018. Published by Elsevier Taiwan LLC.
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