Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt

Animals Cell Differentiation Colitis / chemically induced Disease Models, Animal Disease Progression Gastrointestinal Microbiome / genetics Homeostasis Humans Inflammatory Bowel Diseases / immunology Mice Mice, Inbred C57BL Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism RNA, Ribosomal, 16S / genetics T-Lymphocytes, Regulatory / immunology Th17 Cells / metabolism

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
15 01 2019
Historique:
received: 03 05 2018
revised: 03 10 2018
accepted: 13 12 2018
entrez: 17 1 2019
pubmed: 17 1 2019
medline: 6 7 2019
Statut: ppublish

Résumé

Microbiota are thought to influence the development and progression of inflammatory bowel disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires larger-scale functional analyses. We colonized germ-free mice with intestinal microbiotas from 30 healthy and IBD donors and determined the homeostatic intestinal T cell response to each microbiota. Compared to microbiotas from healthy donors, transfer of IBD microbiotas into germ-free mice increased numbers of intestinal Th17 cells and Th2 cells and decreased numbers of RORγt

Identifiants

DOI: 10.1016/j.immuni.2018.12.015 PMID: 30650377 PMC: PMC6512335
pubmed: 30650377
pii: S1074-7613(18)30563-6
doi: 10.1016/j.immuni.2018.12.015
pmc: PMC6512335
mid: NIHMS1020418
pii:
doi:

Substances chimiques

Nuclear Receptor Subfamily 1, Group F, Member 3 0
RNA, Ribosomal, 16S 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

212-224.e4

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190400
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK108487
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108505
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK112679
Pays : United States
Organisme : NIAID NIH HHS
ID : U24 AI118644
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK041301
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK085691
Pays : United States
Organisme : NIDDK NIH HHS
ID : P01 DK046763
Pays : United States
Organisme : NCCIH NIH HHS
ID : P50 AT008661
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Graham J Britton (GJ)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Eduardo J Contijoch (EJ)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ilaria Mogno (I)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Olivia H Vennaro (OH)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Sean R Llewellyn (SR)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ruby Ng (R)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Zhihua Li (Z)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Arthur Mortha (A)

The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Immunology, University of Toronto, Toronto, ON, Canada.

Miriam Merad (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Anuk Das (A)

Janssen Human Microbiome Institute, Janssen Research and Development, LLC, Spring House, PA, USA.

Dirk Gevers (D)

Janssen Human Microbiome Institute, Janssen Research and Development, LLC, Spring House, PA, USA.

Dermot P B McGovern (DPB)

Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Namita Singh (N)

Pediatric Gastroenterology and Inflammatory Bowel Disease, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jonathan Braun (J)

UCLA David Geffen School of Medicine, Los Angeles, CA, USA.

Jonathan P Jacobs (JP)

Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Jose C Clemente (JC)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ari Grinspan (A)

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bruce E Sands (BE)

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Jean-Frederic Colombel (JF)

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Marla C Dubinsky (MC)

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Jeremiah J Faith (JJ)

Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: jeremiah.faith@mssm.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Microbiotas from Humans with Inflammatory...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Microbiotas from Humans with Inflammatory...