Mechanisms of Communication in the Mammalian Circadian Timing System.
circadian clocks
entrainment
peripheral clocks
resetting
suprachiasmatic nucleus (SCN)
zeitgeber
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
received:
18
12
2018
revised:
08
01
2019
accepted:
10
01
2019
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
30
4
2019
Statut:
epublish
Résumé
24-hour rhythms in physiology and behaviour are organized by a body-wide network of endogenous circadian clocks. In mammals, a central pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) integrates external light information to adapt cellular clocks in all tissues and organs to the external light-dark cycle. Together, central and peripheral clocks co-regulate physiological rhythms and functions. In this review, we outline the current knowledge about the routes of communication between the environment, the main pacemakers and the downstream clocks in the body, focusing on what we currently know and what we still need to understand about the communication mechanisms by which centrally and peripherally controlled timing signals coordinate physiological functions and behaviour. We highlight recent findings that shed new light on the internal organization and function of the SCN and neuroendocrine mechanisms mediating clock-to-clock coupling. These findings have implications for our understanding of circadian network entrainment and for potential manipulations of the circadian clock system in therapeutic settings.
Identifiants
pubmed: 30650649
pii: ijms20020343
doi: 10.3390/ijms20020343
pmc: PMC6359556
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : AS547-1/1
Organisme : Deutsche Forschungsgemeinschaft
ID : OS353-7/1
Organisme : Volkswagen Foundation
ID : Lichternberg Fellowship (HO)
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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