Equine Herpesvirus 1 Bridles T Lymphocytes To Reach Its Target Organs.
Animals
Cells, Cultured
Endothelial Cells
/ immunology
Epithelial Cells
/ immunology
Herpesviridae Infections
/ immunology
Herpesvirus 1, Equid
/ immunology
Horse Diseases
/ immunology
Horses
/ immunology
Immune Evasion
/ immunology
Monocytes
/ immunology
Respiratory Mucosa
/ immunology
T-Lymphocytes
/ immunology
Viral Proteins
/ immunology
Viremia
/ immunology
Virus Replication
/ immunology
Equidae
T lymphocytes
equine herpesvirus
immune evasion
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
22
11
2018
accepted:
03
01
2019
pubmed:
18
1
2019
medline:
19
11
2019
entrez:
18
1
2019
Statut:
epublish
Résumé
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic cells and T lymphocytes, transmit EHV1 to endothelial cells of the endometrium or central nervous system, causing reproductive (abortigenic variants) or neurological (neurological variants) disorders. In the present study, we questioned the potential route of EHV1 infection of T lymphocytes and how EHV1 misuses T lymphocytes as a vehicle to reach the endothelium of the target organs in the absence or presence of immune surveillance. Viral replication was evaluated in activated and quiescent primary T lymphocytes, and the results demonstrated increased infection of activated versus quiescent, CD4
Identifiants
pubmed: 30651370
pii: JVI.02098-18
doi: 10.1128/JVI.02098-18
pmc: PMC6430527
pii:
doi:
Substances chimiques
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Poelaert et al.
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