Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats.
Animals
Cocaine
/ pharmacology
Conditioning, Psychological
/ drug effects
Dopamine Uptake Inhibitors
/ pharmacology
Dose-Response Relationship, Drug
Male
Memory Consolidation
/ drug effects
Nicotine
/ pharmacology
Nicotinic Agonists
/ pharmacology
Nootropic Agents
/ pharmacology
Rats, Sprague-Dawley
Recognition, Psychology
/ drug effects
Substance-Related Disorders
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN: 1549-5485
Titre abrégé: Learn Mem
Pays: United States
ID NLM: 9435678
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
03
10
2018
accepted:
18
12
2018
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
15
1
2020
Statut:
epublish
Résumé
To test the hypothesis that drugs of abuse and their conditioned stimuli (CSs) enhance memory consolidation, the effects of post-training exposure to cocaine and nicotine were compared to the effects of post-training exposure to contextual stimuli that were paired with the effects of these drugs. Using the object recognition (OR) task, it was first demonstrated that both 10 and 20 mg/kg cocaine, and 0.2 and 0.4 mg/kg nicotine, enhanced recognition memory when administered immediately after, but not 6 h after the sample phase. To establish the drug CSs, rats were confined for 2 h in a chamber (the CS+) after injections of 20 mg/kg cocaine, or 0.4 mg/kg nicotine, and in another chamber (the CS-) after injections of vehicle. This was repeated over 10 d (5 drug/CS+ and 5 vehicle/CS- pairings in total). At the end of this conditioning period, when tested in a drug-free state, rats displayed conditioned hyperactivity in the CS+ relative to the CS-. More important, immediate, but not delayed, post-sample exposure to the cocaine CS+, or nicotine CS+, enhanced OR memory. Therefore, this study reports for the first time that contextual stimuli paired with cocaine and nicotine, like the drugs themselves, have the ability to enhance memory consolidation.
Identifiants
pubmed: 30651377
pii: 26/2/46
doi: 10.1101/lm.048579.118
pmc: PMC6340119
doi:
Substances chimiques
Dopamine Uptake Inhibitors
0
Nicotinic Agonists
0
Nootropic Agents
0
Nicotine
6M3C89ZY6R
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-55Informations de copyright
© 2019 Wolter et al.; Published by Cold Spring Harbor Laboratory Press.
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