Early preclinical detection of prions in the skin of prion-infected animals.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 01 2019
16 01 2019
Historique:
received:
18
05
2018
accepted:
07
12
2018
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
21
3
2019
Statut:
epublish
Résumé
A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the feasibility of using skin for preclinical diagnosis, here we report ultrasensitive serial protein misfolding cyclic amplification (sPMCA) and real-time quaking-induced conversion (RT-QuIC) assays of skin samples from hamsters and humanized transgenic mice (Tg40h) at different time points after intracerebral inoculation with 263K and sCJDMM1 prions, respectively. sPMCA detects skin PrP
Identifiants
pubmed: 30651538
doi: 10.1038/s41467-018-08130-9
pii: 10.1038/s41467-018-08130-9
pmc: PMC6335425
doi:
Substances chimiques
Antibodies, Monoclonal
0
Biomarkers
0
PrPSc Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
247Subventions
Organisme : NIH HHS
ID : NS062787
Pays : United States
Organisme : NIH HHS
ID : NS088604
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109532
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088604
Pays : United States
Organisme : NIH HHS
ID : NS087588
Pays : United States
Organisme : NIH HHS
ID : NS109532
Pays : United States
Commentaires et corrections
Type : ErratumIn
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