PDB_Amyloid: an extended live amyloid structure list from the PDB.


Journal

FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716

Informations de publication

Date de publication:
01 2019
Historique:
received: 24 05 2018
revised: 21 08 2018
accepted: 03 09 2018
entrez: 18 1 2019
pubmed: 18 1 2019
medline: 18 1 2019
Statut: epublish

Résumé

The Protein Data Bank (PDB) contains more than 135 000 entries at present. From these, relatively few amyloid structures can be identified, since amyloids are insoluble in water. Therefore, most amyloid structures deposited in the PDB are in the form of solid state NMR data. Based on the geometric analysis of these deposited structures, we have prepared an automatically updated web server, which generates a list of the deposited amyloid structures, and also entries of globular proteins that have amyloid-like substructures of given size and characteristics. We have found that by applying only appropriately selected geometric conditions, it is possible to identify deposited amyloid structures and a number of globular proteins with amyloid-like substructures. We have analyzed these globular proteins and have found proof in the literature that many of them form amyloids more easily than many other globular proteins. Our results relate to the method of Stanković

Identifiants

pubmed: 30652085
doi: 10.1002/2211-5463.12524
pii: FEB412524
pmc: PMC6325586
doi:

Substances chimiques

Amyloid 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

185-190

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Auteurs

Kristóf Takács (K)

PIT Bioinformatics Group Eötvös University Budapest Hungary.

Bálint Varga (B)

PIT Bioinformatics Group Eötvös University Budapest Hungary.

Vince Grolmusz (V)

PIT Bioinformatics Group Eötvös University Budapest Hungary.
Uratim Ltd. Budapest Hungary.

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Classifications MeSH