Immunity and Inflammation in Atherosclerosis.
adaptive immunity
atherosclerosis
immunity
inflammation
myeloid cells
vaccination
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
19
11
2019
Statut:
ppublish
Résumé
There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
Identifiants
pubmed: 30653442
doi: 10.1161/CIRCRESAHA.118.313591
pmc: PMC6342482
mid: NIHMS1517398
doi:
Substances chimiques
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-327Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL088093
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115232
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL121697
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL145241
Pays : United States
Références
Circ Res. 2017 May 26;120(11):1740-1753
pubmed: 28420668
Cardiovasc Res. 2018 Jan 1;114(1):158-167
pubmed: 29016728
Circulation. 2016 Aug 23;134(8):611-24
pubmed: 27496857
Nat Rev Cardiol. 2014 Sep;11(9):516-29
pubmed: 25027488
Nat Med. 2017 May;23(5):601-610
pubmed: 28414328
Eur Heart J. 2008 Sep;29(18):2218-26
pubmed: 18664466
Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1174-85
pubmed: 27102965
Circulation. 2013 Mar 5;127(9):1028-39
pubmed: 23395974
Atherosclerosis. 2006 Feb;184(2):330-41
pubmed: 16051252
Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):101-7
pubmed: 11145940
Nat Med. 2018 Jun;24(6):711-720
pubmed: 29867229
Cardiovasc Res. 2015 Jun 1;106(3):443-52
pubmed: 25681396
N Engl J Med. 2011 Dec 1;365(22):2078-87
pubmed: 22085316
Circulation. 2003 Sep 9;108(10):1232-7
pubmed: 12912803
Circ Res. 2016 May 13;118(10):1540-52
pubmed: 27021296
Autoimmunity. 2015 May;48(3):152-60
pubmed: 25683179
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4642-6
pubmed: 9114044
Atherosclerosis. 2012 Jun;222(2):519-23
pubmed: 22575708
J Exp Med. 2004 Feb 2;199(3):417-22
pubmed: 14744994
Cardiovasc Res. 2018 Aug 1;114(10):1360-1371
pubmed: 29726984
Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1060-H1067
pubmed: 28314764
PLoS One. 2012;7(1):e29371
pubmed: 22238605
Trends Immunol. 2011 Nov;32(11):540-7
pubmed: 21835696
Circ Res. 2016 Nov 11;119(11):1190-1203
pubmed: 27635087
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):454-60
pubmed: 12615659
Circulation. 2011 Jul 12;124(2):185-95
pubmed: 21690490
J Clin Invest. 1997 Jun 1;99(11):2752-61
pubmed: 9169506
Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):605-12
pubmed: 22223728
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1049-54
pubmed: 14988092
Immunity. 2007 Aug;27(2):203-13
pubmed: 17707129
Thromb Haemost. 2011 Nov;106(5):858-67
pubmed: 22012133
Circ Res. 2018 Jun 8;122(12):1661-1674
pubmed: 29545365
Circulation. 2018 Jul 10;138(2):131-140
pubmed: 29530884
Eur J Immunol. 2018 Sep;48(9):1580-1587
pubmed: 29932463
J Lipid Res. 2009 Apr;50 Suppl:S364-9
pubmed: 19050311
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1506-16
pubmed: 21677293
J Am Coll Cardiol. 2001 Sep;38(3):900-5
pubmed: 11527651
Circ Res. 2015 Jul 17;117(3):e28-39
pubmed: 26082558
Circulation. 2012 Sep 4;126(10):1256-66
pubmed: 22851544
Circ Res. 2009 Jun 19;104(12):e62-70
pubmed: 19478203
J Am Coll Cardiol. 2007 Dec 11;50(24):2313-8
pubmed: 18068040
Nat Commun. 2018 Mar 15;9(1):1095
pubmed: 29545616
Circ Res. 2014 May 23;114(11):1743-56
pubmed: 24855199
Thromb Haemost. 2015 Oct;114(4):835-47
pubmed: 26063196
Mol Med. 2003 Jan-Feb;9(1-2):10-7
pubmed: 12765335
N Engl J Med. 2008 Nov 20;359(21):2195-207
pubmed: 18997196
Arterioscler Thromb Vasc Biol. 2010 May;30(5):946-52
pubmed: 20167655
Circulation. 2014 Oct 14;130(16):1363-73
pubmed: 25223984
Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):456-61
pubmed: 11884290
Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H781-H790
pubmed: 28087520
Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):637-44
pubmed: 23307873
J Clin Invest. 2012 Sep;122(9):3114-26
pubmed: 22886300
J Clin Invest. 2009 May;119(5):1335-49
pubmed: 19363291
Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1892-8
pubmed: 12426221
Clin Sci (Lond). 2001 Nov;101(5):523-31
pubmed: 11672458
Nat Med. 2006 Feb;12(2):178-80
pubmed: 16462800
Circulation. 2010 Apr 20;121(15):1746-55
pubmed: 20368519
Circulation. 2014 Apr 22;129(16):1677-87
pubmed: 24488984
Circ Res. 2016 Feb 19;118(4):547-63
pubmed: 26892957
J Lipid Res. 2007 Feb;48(2):425-33
pubmed: 17093289
J Clin Invest. 1993 Aug;92(2):883-93
pubmed: 8349823
Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):429-38
pubmed: 26821946
Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):10-7
pubmed: 10634795
Circulation. 2016 Jan 19;133(3):256-64
pubmed: 26659948
Sci Transl Med. 2013 Jul 31;5(196):196ra100
pubmed: 23903754
Nat Med. 2007 Apr;13(4):423-31
pubmed: 17384649
Arteriosclerosis. 1986 Mar-Apr;6(2):131-8
pubmed: 2937395
Circulation. 2007 Oct 16;116(16):1801-11
pubmed: 17909108
Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1770-3
pubmed: 26088575
J Lipid Res. 2001 Sep;42(9):1474-82
pubmed: 11518768
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2030-8
pubmed: 25848033
Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2847-53
pubmed: 10591660
PLoS Genet. 2016 Mar 02;12(3):e1005913
pubmed: 26934746
Arterioscler Thromb. 1994 Jan;14(1):32-40
pubmed: 7506053
Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):95-100
pubmed: 11145939
J Clin Invest. 2002 Mar;109(6):745-53
pubmed: 11901183
Lancet. 2012 Aug 11;380(9841):581-90
pubmed: 22607822
N Engl J Med. 2015 Apr 16;372(16):1489-99
pubmed: 25773378
Atherosclerosis. 2012 Jan;220(1):59-65
pubmed: 22062590
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
Nat Commun. 2017 Jul 24;8:16041
pubmed: 28737175
Circulation. 2011 Mar 15;123(10):1083-91
pubmed: 21357823
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1596-601
pubmed: 15665085
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):864-70
pubmed: 16456097
Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):765-71
pubmed: 26916732
Circulation. 2004 Oct 5;110(14):2047-52
pubmed: 15451805
Atherosclerosis. 1988 Aug;72(2-3):135-41
pubmed: 3063267
Front Immunol. 2013 Dec 27;4:493
pubmed: 24416033
J Clin Invest. 1999 Jan;103(1):117-28
pubmed: 9884341
Cardiovasc Res. 2014 Apr 1;102(1):128-37
pubmed: 24469537
BMC Immunol. 2010 Dec 02;11:58
pubmed: 21126329
J Intern Med. 2011 May;269(5):546-56
pubmed: 21114693
Circulation. 2018 Sep 11;138(11):1130-1143
pubmed: 29588316
BMC Cardiovasc Disord. 2016 Jan 29;16:26
pubmed: 26822994
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):763-70
pubmed: 25675999
Expert Rev Cardiovasc Ther. 2012 Apr;10(4):399-402
pubmed: 22458571
Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):628-32
pubmed: 15591216
Nat Rev Immunol. 2015 Feb;15(2):104-16
pubmed: 25614320
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):879-84
pubmed: 12649092
Science. 1976 Sep 17;193(4258):1094-100
pubmed: 822515
Circulation. 2004 Jun 1;109(21 Suppl 1):II18-26
pubmed: 15173059
JACC Cardiovasc Imaging. 2015 Apr;8(4):493-494
pubmed: 25457756
Sci Rep. 2017 Nov 15;7(1):15655
pubmed: 29142309
N Engl J Med. 2017 May 4;376(18):1713-1722
pubmed: 28304224
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):280-7
pubmed: 25414253
Circ Res. 2014 May 9;114(10):1640-60
pubmed: 24812352
Eur Heart J. 2006 Nov;27(21):2530-7
pubmed: 16954132
Nature. 2010 Apr 29;464(7293):1357-61
pubmed: 20428172
J Exp Med. 2010 Aug 2;207(8):1579-87
pubmed: 20603314
J Clin Invest. 2013 Mar;123(3):1323-34
pubmed: 23426179
Circ Res. 2016 Feb 19;118(4):535-46
pubmed: 26892956
J Exp Med. 2006 May 15;203(5):1273-82
pubmed: 16682495
J Clin Invest. 2016 Sep 1;126(9):3236-46
pubmed: 27482882
Nature. 2018 Jun;558(7709):301-306
pubmed: 29875409
Eur Heart J. 2017 Nov 14;38(43):3195-3201
pubmed: 29020241
Nature. 2015 Feb 5;518(7537):102-6
pubmed: 25487149
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Nat Med. 2014 Jan;20(1):62-8
pubmed: 24362934
J Clin Invest. 2001 Jul;108(2):251-9
pubmed: 11457878
Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2421-32
pubmed: 16973967
Cardiovasc Res. 2014 Apr 1;102(1):107-17
pubmed: 24403315
Cell Mol Life Sci. 2015 Oct;72(20):3853-69
pubmed: 26100516
Nat Med. 2013 Jun;19(6):739-46
pubmed: 23624599
Basic Res Cardiol. 2016 Nov;111(6):71
pubmed: 27783202
Circ Res. 2018 May 11;122(10):1385-1394
pubmed: 29618596
Circulation. 2001 Feb 27;103(8):1071-5
pubmed: 11222468
Immunity. 2013 Nov 14;39(5):949-62
pubmed: 24238343
N Engl J Med. 2011 Jan 20;364(3):226-35
pubmed: 21247313
Lancet. 2018 Nov 17;392(10160):2203-2212
pubmed: 30195398
Nature. 2002 Dec 19-26;420(6917):868-74
pubmed: 12490960
J Exp Med. 2010 May 10;207(5):1081-93
pubmed: 20439543
J Clin Invest. 2004 Jul;114(2):300-8
pubmed: 15254597
Circ Res. 2016 Feb 19;118(4):564-78
pubmed: 26892958
J Immunol. 2010 Oct 1;185(7):4410-9
pubmed: 20817865
Oncotarget. 2017 Aug 3;8(59):99312-99322
pubmed: 29245903
Circulation. 2018 Nov 27;138(22):2513-2526
pubmed: 29997115
Nat Med. 2003 Jun;9(6):736-43
pubmed: 12740573
Arterioscler Thromb Vasc Biol. 2018 May;38(5):e71-e84
pubmed: 29599140
Cardiovasc Res. 2016 Feb 1;109(2):305-17
pubmed: 26604037
Circ Res. 2018 Jan 5;122(1):6-7
pubmed: 29301835
J Am Coll Cardiol. 2017 Oct 31;70(18):2278-2289
pubmed: 29073957
N Engl J Med. 2019 Feb 21;380(8):752-762
pubmed: 30415610
Circ Res. 2011 Sep 30;109(8):830-40
pubmed: 21868694
Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1282-92
pubmed: 20554950
Front Cardiovasc Med. 2015 May 20;2:17
pubmed: 26664889
Circ Res. 2018 Jun 8;122(12):1675-1688
pubmed: 29545366
J Am Coll Cardiol. 2018 Jan 23;71(3):321-335
pubmed: 29348025
J Lipid Res. 2011 Oct;52(10):1829-36
pubmed: 21821825
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):e145-e158
pubmed: 29880490
Am J Pathol. 1996 Aug;149(2):675-85
pubmed: 8702005
J Immunol. 2010 Nov 15;185(10):5820-7
pubmed: 20952673
Circulation. 2009 Aug 4;120(5):417-26
pubmed: 19620499
Nature. 2016 Apr 28;532(7600):512-6
pubmed: 27096360
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):2000-4
pubmed: 22628434
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):273-80
pubmed: 22116098
JACC Basic Transl Sci. 2018 Jan 10;3(1):54-66
pubmed: 30062194
Circ Res. 2018 Oct 26;123(10):1118-1120
pubmed: 30359201
Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):821-5
pubmed: 7846059
Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1341-6
pubmed: 12171798
J Exp Med. 2009 Jan 16;206(1):233-48
pubmed: 19139167
J Intern Med. 2017 Apr;281(4):383-397
pubmed: 28194913
Science. 1992 Oct 16;258(5081):468-71
pubmed: 1411543
Front Immunol. 2017 Feb 23;8:95
pubmed: 28280493
Circulation. 2003 Oct 28;108(17):2107-12
pubmed: 14530200
Br J Clin Pharmacol. 2016 Jun;81(6):1175-90
pubmed: 26861255
J Am Coll Cardiol. 2011 Oct 11;58(16):1715-27
pubmed: 21982317
Atherosclerosis. 1999 Aug;145(2):301-8
pubmed: 10488957
Arterioscler Thromb. 1991 Sep-Oct;11(5):1223-30
pubmed: 1911708
Circ Res. 2016 Feb 19;118(4):620-36
pubmed: 26892962
Annu Rev Immunol. 2004;22:531-62
pubmed: 15032588
J Clin Invest. 2003 Nov;112(9):1342-50
pubmed: 14568988
Arterioscler Thromb Vasc Biol. 1998 Dec;18(12):1972-82
pubmed: 9848892
Circ Res. 2017 Jul 21;121(3):270-281
pubmed: 28620068
J Am Coll Cardiol. 2015 Feb 17;65(6):546-56
pubmed: 25677313
Cardiovasc Diabetol. 2014 Nov 13;13:151
pubmed: 25391642
Annu Rev Immunol. 2012;30:1-22
pubmed: 22136168
J Am Coll Cardiol. 2013 Jan 29;61(4):404-410
pubmed: 23265346
Circ Res. 2018 Jan 5;122(1):47-57
pubmed: 29046274
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3893-7
pubmed: 7732003
Atherosclerosis. 2013 Jun;228(2):346-52
pubmed: 23566804
Eur Heart J Acute Cardiovasc Care. 2012 Apr;1(1):9-12
pubmed: 24062883
J Lipid Res. 2009 Apr;50 Suppl:S340-5
pubmed: 18980945
Circ Res. 2008 Aug 29;103(5):467-76
pubmed: 18658050
Eur Heart J. 2014 May;35(17):1112-9
pubmed: 24595865
Lancet. 1959 Jul 4;2(7088):6-7
pubmed: 13673567