Inhibitory checkpoint receptors control CD8
Allergens
Animals
CD8-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Dermatitis, Allergic Contact
/ immunology
Dinitrofluorobenzene
Female
Hepatitis A Virus Cellular Receptor 2
/ immunology
Immunologic Memory
Mice, Inbred C57BL
Oxazolone
Programmed Cell Death 1 Receptor
/ immunology
Severity of Illness Index
Skin
/ immunology
Resident memory T cells
allergic contact dermatitis
eczema
immunopathology
inhibitory check point receptors
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
06
2018
revised:
13
10
2018
accepted:
16
11
2018
pubmed:
18
1
2019
medline:
9
6
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
Tissue-resident memory T (Trm) cells are detrimental in patients with numerous chronic inflammatory diseases, including allergic contact dermatitis (ACD). We sought to analyze the contribution of Trm cells to the chronicity and severity of ACD and to define the local parameters regulating their development and functions. We used an experimental model of ACD (ie, contact hypersensitivity to 2,4-dinitrofluorobenzene) that is mediated by CD8 Our data show that early effector T cells accumulated in the skin during the acute contact hypersensitivity reaction and gave rise to epidermal CD8 Although CD8
Sections du résumé
BACKGROUND
Tissue-resident memory T (Trm) cells are detrimental in patients with numerous chronic inflammatory diseases, including allergic contact dermatitis (ACD).
OBJECTIVES
We sought to analyze the contribution of Trm cells to the chronicity and severity of ACD and to define the local parameters regulating their development and functions.
METHODS
We used an experimental model of ACD (ie, contact hypersensitivity to 2,4-dinitrofluorobenzene) that is mediated by CD8
RESULTS
Our data show that early effector T cells accumulated in the skin during the acute contact hypersensitivity reaction and gave rise to epidermal CD8
CONCLUSION
Although CD8
Identifiants
pubmed: 30654051
pii: S0091-6749(19)30015-6
doi: 10.1016/j.jaci.2018.11.048
pii:
doi:
Substances chimiques
Allergens
0
Havcr2 protein, mouse
0
Hepatitis A Virus Cellular Receptor 2
0
Pdcd1 protein, mouse
0
Programmed Cell Death 1 Receptor
0
Oxazolone
15646-46-5
Dinitrofluorobenzene
D241E059U6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2147-2157.e9Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.