Human neutrophils express low levels of FcγRIIIA, which plays a role in PMN activation.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
19
07
2018
accepted:
09
01
2019
pubmed:
19
1
2019
medline:
4
12
2019
entrez:
19
1
2019
Statut:
ppublish
Résumé
We have identified a rare healthy FcγRIIIB (CD16B)-null donor completely lacking FCGR3B RNA and protein expression and dissected the role of the different neutrophil Fcγ receptors in the response to therapeutic anti-CD20 monoclonal antibodies. We observed that polymorphonuclear neutrophils (PMNs) from FcγRIIIB wild-type (WT) individuals or the null donor were more effectively activated by chronic lymphocytic leukemia (CLL) B-cell targets opsonized with glycoengineered anti-CD20 antibodies compared with fully core-fucosylated anti-CD20 antibodies, suggesting the presence and role of FcγRIIIA (CD16A) on PMNs. Indeed, we demonstrated by reverse-transcription polymerase chain reaction, flow cytometry, and western blot analysis that PMNs from FcγRIIIB WT donors and the null individual express low levels of FcγRIIIA on their surfaces. FcγRIIIA is a functional and activating molecule on these cells, because anti-CD16 F(ab')
Identifiants
pubmed: 30655272
pii: S0006-4971(20)42662-X
doi: 10.1182/blood-2018-07-864538
pmc: PMC6484458
doi:
Substances chimiques
FCGR3A protein, human
0
Immunoglobulin G
0
RNA, Messenger
0
Receptors, IgG
0
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1395-1405Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by The American Society of Hematology.
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