Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells.
Apoptosis Regulatory Proteins
/ metabolism
Cell Line, Tumor
Cell Movement
/ physiology
Colorectal Neoplasms
/ drug therapy
Epithelial Cells
/ enzymology
Epithelial-Mesenchymal Transition
Fluorouracil
/ pharmacology
HCT116 Cells
Humans
Neoplasm Metastasis
Protein Serine-Threonine Kinases
/ metabolism
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
17
09
2018
revised:
27
11
2018
accepted:
08
01
2019
pubmed:
19
1
2019
medline:
10
1
2020
entrez:
19
1
2019
Statut:
ppublish
Résumé
Serine threonine kinase 17A (STK17A) is a ubiquitously expressed kinase originally identified as a regulator of apoptosis; however, whether it functionally contributes to colorectal cancer has not been established. Here, we have analyzed STK17A in colorectal cancer and demonstrated decreased expression of STK17A in primary tumors, which is further reduced in metastatic lesions, indicating a potential role in regulating the metastatic cascade. Interestingly, changes in STK17A expression did not modify proliferation, apoptosis, or sensitivity of colorectal cancer cell lines to treatment with the chemotherapeutic 5-fluorouracil. Instead,
Identifiants
pubmed: 30655319
pii: 1541-7786.MCR-18-0990
doi: 10.1158/1541-7786.MCR-18-0990
pmc: PMC6941354
mid: NIHMS1518808
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
STK17A protein, human
EC 2.7.11.1
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
882-894Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK099204
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK080221
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK111107
Pays : United States
Organisme : BLRD VA
ID : I01 BX001426
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA236733
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK108492
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
Références
Cancer Res. 1981 May;41(5):1751-6
pubmed: 7214343
Anticancer Drugs. 2007 Jul;18(6):633-9
pubmed: 17762391
Gastroenterology. 2011 Nov;141(5):1762-72
pubmed: 21889923
Nat Rev Cancer. 2017 Mar;17(3):145-159
pubmed: 28154375
J Clin Invest. 2011 Oct;121(10):4056-69
pubmed: 21911938
Biomaterials. 2012 Nov;33(33):8189-203
pubmed: 22940214
J Biol Chem. 2004 Aug 20;279(34):35557-63
pubmed: 15205456
Cancer Res. 1976 Dec;36(12):4562-9
pubmed: 1000501
Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96
pubmed: 24556840
J Biol Chem. 2011 Jun 3;286(22):19381-91
pubmed: 21489989
Biochem Biophys Res Commun. 2018 Feb 19;496(4):1222-1228
pubmed: 29397938
Nat Rev Cancer. 2005 Sep;5(9):744-9
pubmed: 16148886
J Cell Biochem. 1999 Jun 15;73(4):488-99
pubmed: 10733343
Cell Rep. 2013 Apr 25;3(4):1128-39
pubmed: 23545496
Cancer Med. 2013 Dec;2(6):836-48
pubmed: 24403257
Nature. 2012 Mar 28;483(7391):603-7
pubmed: 22460905
PLoS Med. 2013;10(5):e1001453
pubmed: 23700391
Cell. 2017 Feb 9;168(4):670-691
pubmed: 28187288
Front Oncol. 2015 Jul 20;5:155
pubmed: 26258068
Trends Cancer. 2016 Feb;2(2):65-67
pubmed: 27042694
Oncogene. 2005 Sep 8;24(40):6090-100
pubmed: 15940259
J Cell Sci. 2003 Apr 15;116(Pt 8):1617-25
pubmed: 12640045
Nat Cell Biol. 2001 Apr;3(4):339-45
pubmed: 11283606
Anticancer Res. 2010 Feb;30(2):653-60
pubmed: 20332485
Biochim Biophys Acta. 2009 Dec;1796(2):75-90
pubmed: 19306912
Nat Rev Mol Cell Biol. 2009 Nov;10(11):778-90
pubmed: 19851336
CA Cancer J Clin. 2017 May 6;67(3):177-193
pubmed: 28248415
Oncol Lett. 2016 Aug;12(2):1107-1112
pubmed: 27446402
Cell Res. 2009 Jan;19(1):89-102
pubmed: 19050696
Cancer Res. 2002 Nov 15;62(22):6698-705
pubmed: 12438269
PLoS One. 2013 Nov 28;8(11):e81803
pubmed: 24312360
J Cell Biol. 2015 Aug 17;210(4):613-27
pubmed: 26261179
Oncogene. 2015 Sep 24;34(39):5037-45
pubmed: 25531329
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9719-23
pubmed: 11481457
J Biol Chem. 1998 Oct 30;273(44):29066-71
pubmed: 9786912
Nat Cell Biol. 2005 Mar;7(3):255-61
pubmed: 15723050
Cytokine Growth Factor Rev. 1996 Jun;7(1):93-102
pubmed: 8864357
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Cell Stem Cell. 2010 Aug 6;7(2):240-8
pubmed: 20682449
Nat Cell Biol. 2013 Mar;15(3):261-73
pubmed: 23417122
Cancer Treat Res. 2010;155:85-103
pubmed: 20517689
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
Science. 2011 Mar 25;331(6024):1559-64
pubmed: 21436443
PLoS One. 2015 May 07;10(5):e0123650
pubmed: 25951457
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3087-91
pubmed: 10077641
Cell Rep. 2012 Nov 29;2(5):1286-99
pubmed: 23122956
Tumori. 2009 Nov-Dec;95(6):796-803
pubmed: 20210246
Cell Death Differ. 2005 Nov;12 Suppl 2:1473-7
pubmed: 16247493
Curr Colorectal Cancer Rep. 2017 Jun;13(3):183-191
pubmed: 29276469
Gastroenterology. 2010 Mar;138(3):958-68
pubmed: 19914252
Genome Biol. 2006;7(10):R100
pubmed: 17076895
Dev Dyn. 2005 Jul;233(3):706-20
pubmed: 15937929