Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.
Animals
Axons
Brain
/ diagnostic imaging
Dendritic Spines
Drosophila
Female
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Kidney
/ diagnostic imaging
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Fluorescence
Nanotechnology
Neuroimaging
/ methods
Optical Imaging
/ methods
Phantoms, Imaging
Somatosensory Cortex
/ diagnostic imaging
Synapses
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
received:
19
07
2018
accepted:
30
11
2018
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
26
7
2019
Statut:
ppublish
Résumé
Optical and electron microscopy have made tremendous inroads toward understanding the complexity of the brain. However, optical microscopy offers insufficient resolution to reveal subcellular details, and electron microscopy lacks the throughput and molecular contrast to visualize specific molecular constituents over millimeter-scale or larger dimensions. We combined expansion microscopy and lattice light-sheet microscopy to image the nanoscale spatial relationships between proteins across the thickness of the mouse cortex or the entire
Identifiants
pubmed: 30655415
pii: 363/6424/eaau8302
doi: 10.1126/science.aau8302
pmc: PMC6481610
mid: NIHMS1010815
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Video-Audio Media
Langues
eng
Subventions
Organisme : NIDA NIH HHS
ID : R01 DA045549
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA029639
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102727
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015478
Pays : United States
Organisme : NIMH NIH HHS
ID : R44 MH093011
Pays : United States
Organisme : NHGRI NIH HHS
ID : RM1 HG008525
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS087950
Pays : United States
Organisme : NINDS NIH HHS
ID : DP1 NS087724
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110932
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM075252
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB024261
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM103792
Pays : United States
Organisme : NIMH NIH HHS
ID : R41 MH112318
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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