An amygdalar neural ensemble that encodes the unpleasantness of pain.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
received:
19
11
2017
accepted:
13
12
2018
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
26
7
2019
Statut:
ppublish
Résumé
Pain is an unpleasant experience. How the brain's affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimuli, withdrawal reflexes, anxiety, or reward. Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to drive dysfunctional perceptual changes associated with neuropathic pain, including pain aversion to light touch (allodynia). These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception.
Identifiants
pubmed: 30655440
pii: 363/6424/276
doi: 10.1126/science.aap8586
pmc: PMC6450685
mid: NIHMS1013456
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
276-281Subventions
Organisme : NIDA NIH HHS
ID : K99 DA043609
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106301
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA044481
Pays : United States
Organisme : NIDA NIH HHS
ID : F32 DA041029
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA031777
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA035165
Pays : United States
Informations de copyright
Copyright © 2019, American Association for the Advancement of Science.
Références
Pain. 1999 May;81(1-2):211-4
pubmed: 10353510
Science. 2000 Jun 9;288(5472):1769-72
pubmed: 10846154
J Neurosci. 2003 Jan 1;23(1):52-63
pubmed: 12514201
Bull Soc Fr Dermatol Syphiligr. 1964 Mar-Apr;71:292-4
pubmed: 14188400
J Neurosci. 2006 Feb 8;26(6):1833-43
pubmed: 16467532
Trends Neurosci. 2006 May;29(5):272-9
pubmed: 16545468
Annu Rev Neurosci. 2009;32:1-32
pubmed: 19400724
Annu Rev Neurosci. 2010;33:173-202
pubmed: 20331363
J Neurosci. 2010 Apr 14;30(15):5451-64
pubmed: 20392966
Pain. 2012 Apr;153(4):885-92
pubmed: 22365310
Neuron. 2012 Feb 23;73(4):638-52
pubmed: 22365541
J Neurosci. 2013 Jan 9;33(2):722-33
pubmed: 23303950
Nat Neurosci. 2013 Mar;16(3):264-6
pubmed: 23396101
Neuron. 2013 Jun 5;78(5):773-84
pubmed: 23764283
Brain. 2013 Sep;136(Pt 9):2751-68
pubmed: 23983029
Pain. 2014 Sep;155(9):1727-42
pubmed: 24861582
Nature. 2015 Jan 15;517(7534):284-92
pubmed: 25592533
J Neurosci. 2015 Feb 25;35(8):3470-7
pubmed: 25716846
Handb Exp Pharmacol. 2015;227:261-84
pubmed: 25846623
Nature. 2015 Apr 30;520(7549):675-8
pubmed: 25925480
Cell. 2015 Jul 2;162(1):134-45
pubmed: 26140594
Cell. 2015 Jul 16;162(2):363-374
pubmed: 26186190
Neuron. 2015 Aug 5;87(3):474-91
pubmed: 26247858
Neuron. 2016 Feb 17;89(4):683-94
pubmed: 26889809
Nat Neurosci. 2016 Dec;19(12):1636-1646
pubmed: 27749826
Neuron. 2016 Oct 19;92(2):294-297
pubmed: 27764663
Science. 2016 Nov 4;354(6312):578-584
pubmed: 27811268
Science. 2016 Nov 4;354(6312):584-587
pubmed: 27811269
Pain. 2017 Mar;158(3):488-497
pubmed: 28135213
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2016-E2025
pubmed: 28202735
Science. 2017 Mar 10;355(6329):1026-1027
pubmed: 28280170
Nature. 2017 Mar 30;543(7647):670-675
pubmed: 28329757
Nat Neurosci. 2017 Jun;20(6):824-835
pubmed: 28436980
N Engl J Med. 2017 Jul 27;377(4):391-394
pubmed: 28564549
Science. 2017 Aug 4;357(6350):503-507
pubmed: 28774929
Cell Rep. 2018 Jan 23;22(4):905-918
pubmed: 29386133
Nature. 2018 May;557(7704):177-182
pubmed: 29720658
Annu Rev Neurosci. 2018 Jul 8;41:453-473
pubmed: 29852083
Behav Neurosci. 1985 Dec;99(6):1031-9
pubmed: 3843537
Confin Neurol. 1966;27(1):53-5
pubmed: 5955974