Radiological characteristics of myelin oligodendrocyte glycoprotein antibody disease.
Adult
Autoantibodies
/ blood
Brain
/ diagnostic imaging
Demyelinating Autoimmune Diseases, CNS
/ blood
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis
/ diagnostic imaging
Myelin-Oligodendrocyte Glycoprotein
/ immunology
Myelitis, Transverse
/ diagnostic imaging
Neuromyelitis Optica
/ diagnostic imaging
Optic Nerve
/ diagnostic imaging
Optic Tract
/ diagnostic imaging
Retrospective Studies
Spinal Cord
/ diagnostic imaging
MOG antibody
Magnetic resonance imaging
NMOSD
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
01
11
2018
revised:
02
01
2019
accepted:
07
01
2019
pubmed:
19
1
2019
medline:
17
7
2019
entrez:
19
1
2019
Statut:
ppublish
Résumé
MOG antibody disease is an autoimmune disease of the central nervous system (CNS) characterized by the presence of a serological antibody against myelin oligodendrocyte glycoprotein (MOG). MRI is instrumental in distinguishing neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS), but MRI features of MOG disease appear to overlap with NMOSD and MS. In this study we aim to characterize the radiological features of MOG antibody disease and compare the findings with those previously described. This is a retrospective study of 26 MOG positive patients. We aim to describe their brain, spinal and orbital MRI features and compare our findings with those previously reported in the literature. The majority of the abnormal findings was located on orbital MRIs, with more involvement of the anterior structures and bilateral involvement of the optic nerves. Brain abnormalities were distinct from both NMOSD and MS lesions. Spinal cord was the least affected. This is a dedicated radiological study aiming to characterize the features of MOG antibody disease which might aid in the proper investigation of cases presenting with acquired demyelinating disorders.
Sections du résumé
BACKGROUND
BACKGROUND
MOG antibody disease is an autoimmune disease of the central nervous system (CNS) characterized by the presence of a serological antibody against myelin oligodendrocyte glycoprotein (MOG). MRI is instrumental in distinguishing neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS), but MRI features of MOG disease appear to overlap with NMOSD and MS.
OBJECTIVES
OBJECTIVE
In this study we aim to characterize the radiological features of MOG antibody disease and compare the findings with those previously described.
METHODS
METHODS
This is a retrospective study of 26 MOG positive patients. We aim to describe their brain, spinal and orbital MRI features and compare our findings with those previously reported in the literature.
RESULTS
RESULTS
The majority of the abnormal findings was located on orbital MRIs, with more involvement of the anterior structures and bilateral involvement of the optic nerves. Brain abnormalities were distinct from both NMOSD and MS lesions. Spinal cord was the least affected.
CONCLUSIONS
CONCLUSIONS
This is a dedicated radiological study aiming to characterize the features of MOG antibody disease which might aid in the proper investigation of cases presenting with acquired demyelinating disorders.
Identifiants
pubmed: 30658259
pii: S2211-0348(19)30021-5
doi: 10.1016/j.msard.2019.01.021
pmc: PMC6431795
mid: NIHMS1518838
pii:
doi:
Substances chimiques
Autoantibodies
0
MOG protein, human
0
Myelin-Oligodendrocyte Glycoprotein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-22Subventions
Organisme : NINDS NIH HHS
ID : K08 NS078555
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130548
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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