In-Cell NMR: Analysis of Protein-Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation.
Animals
Biochemical Phenomena
Drug Discovery
/ methods
Energy Metabolism
/ drug effects
Humans
Metabolic Networks and Pathways
/ drug effects
Metabolomics
/ methods
Nuclear Magnetic Resonance, Biomolecular
/ methods
Phosphorylation
/ drug effects
Protein Processing, Post-Translational
Proteomics
/ methods
Proton Magnetic Resonance Spectroscopy
Structure-Activity Relationship
DNP
in-cell NMR
in-situ NMR
protein NMR
review
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 01 2019
17 01 2019
Historique:
received:
30
11
2018
revised:
11
01
2019
accepted:
13
01
2019
entrez:
20
1
2019
pubmed:
20
1
2019
medline:
2
5
2019
Statut:
epublish
Résumé
Nuclear magnetic resonance (NMR) spectroscopy enables the non-invasive observation of biochemical processes, in living cells, at comparably high spectral and temporal resolution. Preferably, means of increasing the detection limit of this powerful analytical method need to be applied when observing cellular processes under physiological conditions, due to the low sensitivity inherent to the technique. In this review, a brief introduction to in-cell NMR, protein-small molecule interactions, posttranslational phosphorylation, and hyperpolarization NMR methods, used for the study of metabolites in cellulo, are presented. Recent examples of method development in all three fields are conceptually highlighted, and an outlook into future perspectives of this emerging area of NMR research is given.
Identifiants
pubmed: 30658393
pii: ijms20020378
doi: 10.3390/ijms20020378
pmc: PMC6359726
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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