Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL.
Adolescent
Adult
Age Factors
Antineoplastic Agents
/ administration & dosage
Asparaginase
/ administration & dosage
Cell Line, Tumor
DNA Methylation
Drug Resistance, Neoplasm
/ genetics
Epigenesis, Genetic
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Prognosis
Promoter Regions, Genetic
Transcriptome
Young Adult
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
14
06
2018
revised:
29
10
2018
accepted:
15
01
2019
pubmed:
20
1
2019
medline:
30
5
2020
entrez:
20
1
2019
Statut:
ppublish
Résumé
Biological explanation for discrepancies in patient-related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3 We compared TLX1 We show that TLX1 We conclude that
Identifiants
pubmed: 30659025
pii: 1078-0432.CCR-18-1844
doi: 10.1158/1078-0432.CCR-18-1844
doi:
Substances chimiques
Antineoplastic Agents
0
Asparaginase
EC 3.5.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2483-2493Informations de copyright
©2019 American Association for Cancer Research.