DNA methylation in mice is influenced by genetics as well as sex and life experience.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
received:
29
11
2017
accepted:
15
11
2018
entrez:
20
1
2019
pubmed:
20
1
2019
medline:
14
2
2019
Statut:
epublish
Résumé
DNA methylation is an essential epigenetic process in mammals, intimately involved in gene regulation. Here we address the extent to which genetics, sex, and pregnancy influence genomic DNA methylation by intercrossing 2 inbred mouse strains, C57BL/6N and C3H/HeN, and analyzing DNA methylation in parents and offspring using whole-genome bisulfite sequencing. Differential methylation across genotype is detected at thousands of loci and is preserved on parental alleles in offspring. In comparison of autosomal DNA methylation patterns across sex, hundreds of differentially methylated regions are detected. Comparison of animals with different histories of pregnancy within our study reveals a CpG methylation pattern that is restricted to female animals that had borne offspring. Collectively, our results demonstrate the stability of CpG methylation across generations, clarify the interplay of epigenetics with genetics and sex, and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.
Identifiants
pubmed: 30659182
doi: 10.1038/s41467-018-08067-z
pii: 10.1038/s41467-018-08067-z
pmc: PMC6338756
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
305Subventions
Organisme : NIH HHS
ID : ES103146
Pays : United States
Investigateurs
Beatrice B Barnabas
(BB)
Gerard G Bouffard
(GG)
Shelise Y Brooks
(SY)
Holly Coleman
(H)
Lyudmila Dekhtyar
(L)
Xiaobin Guan
(X)
Joel Han
(J)
Shi-Ling Ho
(SL)
Richelle Legaspi
(R)
Quino L Maduro
(QL)
Catherine A Masiello
(CA)
Jennifer C McDowell
(JC)
Cassandra Montemayor
(C)
Morgan Park
(M)
Nancy L Riebow
(NL)
Karen Schandler
(K)
Chanthra Scharer
(C)
Brian Schmidt
(B)
Christina Sison
(C)
Sirintorn Stantripop
(S)
Pamela J Thomas
(PJ)
Meghana Vemulapalli
(M)
Alice C Young
(AC)
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