Exercise increases skin graft resistance to rejection.
Animals
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Female
Graft Rejection
/ etiology
Graft Survival
/ immunology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Physical Conditioning, Animal
/ methods
Skin Transplantation
/ adverse effects
T-Lymphocytes, Regulatory
/ immunology
Transplantation, Homologous
animal models: murine
basic (laboratory) research/science
immunobiology
rejection: T cell mediated (TCMR)
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
10
2018
revised:
03
01
2019
accepted:
09
01
2019
pubmed:
20
1
2019
medline:
5
8
2020
entrez:
20
1
2019
Statut:
ppublish
Résumé
Regular exercise reduces risk of various chronic diseases and can prevent the development and recurrence of cancer, making it a promising nonpharmacological modulator of disease. Yet the effect of regular exercise on solid organ transplant outcome remains uncertain. Using a model of voluntary wheel-running exercise and skin transplantation in mice, we hypothesized that exercise strengthens the alloimmune response, leading to an increased rate of rejection. Instead, we found that regular exercise in mice resulted in prolonged graft survival, with mean allograft survival time increasing by almost 50%. We observed this graft survival extension in exercised mice despite evidence of a slightly enhanced alloimmune response, comprised of increased proliferation of alloreactive CD4
Identifiants
pubmed: 30659772
doi: 10.1111/ajt.15266
pmc: PMC7137356
mid: NIHMS1577408
pii: S1600-6135(22)09090-6
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1560-1567Subventions
Organisme : NIAID NIH HHS
ID : R01 AI115716
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007009
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI132898
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : 1R01AI115716
Pays : International
Informations de copyright
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.
Références
Lancet. 2016 Sep 24;388(10051):1311-24
pubmed: 27475266
Brain Behav Immun. 2014 Jul;39:160-71
pubmed: 24200514
Scand J Med Sci Sports. 2012 Oct;22(5):643-52
pubmed: 21410542
Blood. 2007 Jun 15;109(12):5346-54
pubmed: 17327412
Brain Behav Immun. 2013 Oct;33:46-56
pubmed: 23707215
J Am Soc Nephrol. 2015 Oct;26(10):2341-7
pubmed: 25833841
Blood Adv. 2017 Jun 07;1(14):947-960
pubmed: 29296736
Transplantation. 2016 May;100(5):1015-21
pubmed: 27007226
Ann Oncol. 2014 May;25(5):947-58
pubmed: 24401927
Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):
pubmed: 28507196
Compr Physiol. 2012 Oct;2(4):2775-809
pubmed: 23720265
J Am Coll Cardiol. 2014 Aug 5;64(5):472-81
pubmed: 25082581
Autoimmun Rev. 2018 Jan;17(1):53-72
pubmed: 29108826
Acta Oncol. 2013 Feb;52(2):195-215
pubmed: 23244677
Physiol Rev. 2000 Jul;80(3):1055-81
pubmed: 10893431
J Immunol. 2008 May 1;180(9):5991-9
pubmed: 18424719
Nat Med. 2005 Oct;11(10):1059-65
pubmed: 16155578
Microbiome. 2018 May 25;6(1):96
pubmed: 29793539
J Clin Invest. 2016 Jul 1;126(7):2736-44
pubmed: 27322054
Am J Transplant. 2011 May;11(5):936-46
pubmed: 21449942
Pediatr Exerc Sci. 2009 Aug;21(3):305-17
pubmed: 19827454
Immunity. 2015 Jun 16;42(6):1143-58
pubmed: 26070485
Cell Metab. 2016 Mar 8;23(3):554-62
pubmed: 26895752
Sci Rep. 2018 May 18;8(1):7864
pubmed: 29777149
Diabetes Care. 2002 Sep;25(9):1612-8
pubmed: 12196436
Am J Transplant. 2010 Jul;10(7):1524-33
pubmed: 20642679
Am J Transplant. 2003 Feb;3(2):116-20
pubmed: 12603206
Transplantation. 1983 Oct;36(4):401-5
pubmed: 6226134
PLoS Pathog. 2011 Sep;7(9):e1002252
pubmed: 21966268