Initial Clinical Experience with Stationary Digital Breast Tomosynthesis.
3D mammography
Breast cancer imaging
Digital mammography
Stationary digital breast tomosynthesis
Journal
Academic radiology
ISSN: 1878-4046
Titre abrégé: Acad Radiol
Pays: United States
ID NLM: 9440159
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
09
2018
revised:
26
12
2018
accepted:
27
12
2018
pubmed:
21
1
2019
medline:
25
4
2020
entrez:
21
1
2019
Statut:
ppublish
Résumé
A linear array of carbon nanotube-enabled x-ray sources allows for stationary digital breast tomosynthesis (sDBT), during which projection views are collected without the need to move the x-ray tube. This work presents our initial clinical experience with a first-generation sDBT device. Following informed consent, women with a "suspicious abnormality" (Breast Imaging Reporting and Data System 4), discovered by digital mammography and awaiting biopsy, were also imaged by the first generation sDBT. Four radiologists participated in this paired-image study, completing questionnaires while interpreting the mammograms and sDBT image stacks. Areas under the receiver operating characteristic curve were used to measure reader performance (likelihood of correctly identifying malignancy based on pathology as ground truth), while a multivariate analysis assessed preference, as readers compared one modality to the next when interpreting diagnostically important image features. Findings from 43 women were available for analysis, in whom 12 cases of malignancy were identified by pathology. The mean areas under the receiver operating characteristic curve was significantly higher (p < 0.05) for sDBT than mammography for all breast density categories and breast thicknesses. Additionally, readers preferred sDBT over mammography when evaluating mass margins and shape, architectural distortion, and asymmetry, but preferred mammography when characterizing microcalcifications. Readers preferred sDBT over mammography when interpreting soft-tissue breast features and were diagnostically more accurate using images generated by sDBT in a Breast Imaging Reporting and Data System 4 population. However, the findings also demonstrated the need to improve microcalcification conspicuity, which is guiding both technological and image-processing design changes in future sDBT devices.
Identifiants
pubmed: 30660473
pii: S1076-6332(19)30019-4
doi: 10.1016/j.acra.2018.12.026
pmc: PMC6635094
mid: NIHMS1518954
pii:
doi:
Substances chimiques
Nanotubes, Carbon
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1363-1372Subventions
Organisme : NCI NIH HHS
ID : R01 CA134598
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA151652
Pays : United States
Informations de copyright
Copyright © 2019 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
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